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Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide.

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dc.contributor.author민성길-
dc.date.accessioned2020-07-02T17:42:29Z-
dc.date.available2020-07-02T17:42:29Z-
dc.date.issued1998-
dc.identifier.issn0959-4965-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176994-
dc.description.abstractGinseng total saponins (GTS) injected intracerebroventricularly (i.c.v.) at doses of 0.1-1 microg inhibited the i.c.v. injection stress-induced plasma corticosterone levels in mice. The inhibitory action of GTS was blocked by co-administered N(G)-nitro-L-arginine methyl ester (L-NAME; 1.5 microg, i.c.v.), an inhibitor of nitric oxide synthase (NOS). Of the ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, 20(S)-Rg3 and 20(R)-Rg3 injected i.c.v. at doses of 0.01-1 microg, 20(S)-Rg3 and Rc significantly inhibited the i.c.v. injection stress-induced plasma corticosterone levels. The inhibitory actions of 20(S)-Rg3 and Rc were blocked by co-administered L-NAME (1.5 microg, i.c.v.). These results suggest that GTS, 20(S)-Rg3 and Rc may inhibit the i.c.v. injection stress-induced hypothalamo-pituitary-adrenal response by inducing NO production in the brain.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfNEUROREPORT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCentral Nervous System Agents/administration & dosage-
dc.subject.MESHCentral Nervous System Agents/pharmacology*-
dc.subject.MESHCorticosterone/blood*-
dc.subject.MESHEnzyme Inhibitors/pharmacology-
dc.subject.MESHGinsenosides-
dc.subject.MESHInjections, Intraventricular-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHNG-Nitroarginine Methyl Ester/pharmacology-
dc.subject.MESHNitric Oxide/physiology*-
dc.subject.MESHNitric Oxide Synthase/antagonists & inhibitors-
dc.subject.MESHNitric Oxide Synthase Type I-
dc.subject.MESHSaponins/administration & dosage-
dc.subject.MESHSaponins/pharmacology*-
dc.subject.MESHStress, Psychological/blood*-
dc.titleInhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorDo Hoon Kim-
dc.contributor.googleauthorJun Sub Jung-
dc.contributor.googleauthorHong Won Suh-
dc.contributor.googleauthorSung Oh Huh-
dc.contributor.googleauthorSung-Kil Min-
dc.contributor.googleauthorBong Ki Son-
dc.contributor.googleauthorJung Hill Park-
dc.contributor.googleauthorNak Doo Kim-
dc.contributor.googleauthorYung Hi Kim-
dc.contributor.googleauthorDong Keun Song-
dc.identifier.doi10.1097/00001756-199807130-00021-
dc.contributor.localIdA01404-
dc.relation.journalcodeJ02361-
dc.identifier.eissn1473-558X-
dc.identifier.pmid9694211-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-199807130-00021&LSLINK=80&D=ovft-
dc.contributor.alternativeNameMin, Sung Kil-
dc.contributor.affiliatedAuthor민성길-
dc.citation.volume9-
dc.citation.number4-
dc.citation.startPage2261-
dc.citation.endPage2264-
dc.identifier.bibliographicCitationNEUROREPORT, Vol.9(4) : 2261-2264, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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