Cited 44 times in
Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide.
DC Field | Value | Language |
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dc.contributor.author | 민성길 | - |
dc.date.accessioned | 2020-07-02T17:42:29Z | - |
dc.date.available | 2020-07-02T17:42:29Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176994 | - |
dc.description.abstract | Ginseng total saponins (GTS) injected intracerebroventricularly (i.c.v.) at doses of 0.1-1 microg inhibited the i.c.v. injection stress-induced plasma corticosterone levels in mice. The inhibitory action of GTS was blocked by co-administered N(G)-nitro-L-arginine methyl ester (L-NAME; 1.5 microg, i.c.v.), an inhibitor of nitric oxide synthase (NOS). Of the ginsenosides Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, 20(S)-Rg3 and 20(R)-Rg3 injected i.c.v. at doses of 0.01-1 microg, 20(S)-Rg3 and Rc significantly inhibited the i.c.v. injection stress-induced plasma corticosterone levels. The inhibitory actions of 20(S)-Rg3 and Rc were blocked by co-administered L-NAME (1.5 microg, i.c.v.). These results suggest that GTS, 20(S)-Rg3 and Rc may inhibit the i.c.v. injection stress-induced hypothalamo-pituitary-adrenal response by inducing NO production in the brain. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | NEUROREPORT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Central Nervous System Agents/administration & dosage | - |
dc.subject.MESH | Central Nervous System Agents/pharmacology* | - |
dc.subject.MESH | Corticosterone/blood* | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Ginsenosides | - |
dc.subject.MESH | Injections, Intraventricular | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | NG-Nitroarginine Methyl Ester/pharmacology | - |
dc.subject.MESH | Nitric Oxide/physiology* | - |
dc.subject.MESH | Nitric Oxide Synthase/antagonists & inhibitors | - |
dc.subject.MESH | Nitric Oxide Synthase Type I | - |
dc.subject.MESH | Saponins/administration & dosage | - |
dc.subject.MESH | Saponins/pharmacology* | - |
dc.subject.MESH | Stress, Psychological/blood* | - |
dc.title | Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Do Hoon Kim | - |
dc.contributor.googleauthor | Jun Sub Jung | - |
dc.contributor.googleauthor | Hong Won Suh | - |
dc.contributor.googleauthor | Sung Oh Huh | - |
dc.contributor.googleauthor | Sung-Kil Min | - |
dc.contributor.googleauthor | Bong Ki Son | - |
dc.contributor.googleauthor | Jung Hill Park | - |
dc.contributor.googleauthor | Nak Doo Kim | - |
dc.contributor.googleauthor | Yung Hi Kim | - |
dc.contributor.googleauthor | Dong Keun Song | - |
dc.identifier.doi | 10.1097/00001756-199807130-00021 | - |
dc.contributor.localId | A01404 | - |
dc.relation.journalcode | J02361 | - |
dc.identifier.eissn | 1473-558X | - |
dc.identifier.pmid | 9694211 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-199807130-00021&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Min, Sung Kil | - |
dc.contributor.affiliatedAuthor | 민성길 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 2261 | - |
dc.citation.endPage | 2264 | - |
dc.identifier.bibliographicCitation | NEUROREPORT, Vol.9(4) : 2261-2264, 1998 | - |
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