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The effects of mild hypothermia on Thiopental-Induced EEG suppression

Authors
 Jong Hoon Kim  ;  Sun Ho Kim  ;  Sun Kook Yoo  ;  Jong Yeop Kim  ;  Yong Taek Nam 
Citation
 JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, Vol.10(3) : 137-141, 1998 
Journal Title
 JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY 
ISSN
 0898-4921 
Issue Date
1998
MeSH
Adult ; Beds ; Body Temperature/physiology ; Cerebrovascular Circulation/drug effects ; Cerebrovascular Circulation/physiology ; Electroencephalography/drug effects* ; Female ; Fluid Therapy ; GABA Modulators/administration & dosage ; GABA Modulators/therapeutic use* ; Humans ; Hypothermia, Induced/methods* ; Injections, Intravenous ; Intracranial Aneurysm/surgery* ; Male ; Middle Aged ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/therapeutic use ; Signal Processing, Computer-Assisted ; Thiopental/administration & dosage ; Thiopental/therapeutic use* ; Time Factors
Abstract
Thiopental intravenous injections before temporary clipping and mild hypothermia have protective effects in the setting of cerebral ischemia, and are used clinically in some centers. However, it is not known whether mild hypothermia affects thiopental-induced electroencephalogram (EEG) burst suppression. In this study, the authors compared the onset and duration of EEG suppression by thiopental in normothermic (n=10) and mildly hypothermic (n=10) patients undergoing cerebral aneurysm surgery. Spectral analysis was used to compare the prethiopentonal continuous EEG patterns in normothermic and mild hypothermic patients. The patients' body temperatures were controlled by a circulating water mattress and intravenous fluids (normothermia = 36.4+/-0.1 degrees C, mild hypothermia = 33.3+/-0.1 degrees C). Immediately before temporary clipping, thiopental sodium (5 mg/kg) was administered intravenously. Onset time (the amount of time from thiopental injection to the first complete EEG suppression), duration of suppression (the amount of time from the first complete EEG suppression to recovery on continuous EEG from burst suppression), and maximum duration of isoelectric EEG (the longest time interval between two bursts during burst suppression) were measured. Onset time was shortened (25.8+/-1.4 versus 43.5+/-5.6 seconds), and duration of suppression (531.0+/-56.6 versus 165.0+/-16.9 seconds) and the maximum duration of isoelectric EEG (47.7+/-5.8 versus 22.8+/-2.0 seconds) were prolonged in the patients with mild hypothermia. In two normothermic patients, the standard dose of thiopental did not produce burst suppression, but only a mild decrease in spectral edge frequency. The authors concluded that the effects of mild hypothermia on thiopental-induced EEG suppression are not simply additive, but synergistic.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=ovft&AN=00008506-199807000-00002&PDF=y
DOI
10.1097/00008506-199807000-00002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Yoo, Sun Kook(유선국) ORCID logo https://orcid.org/0000-0002-6032-4686
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176936
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