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Expression and localization of brain Glutamate dehydrogenase with its monoclonal antibody

Authors
 Jong Eun Lee  ;  Soo Young Choi  ;  Sung‐Woo Cho 
Citation
 Korean Journal of Biological Sciences, Vol.2(1) : 71-80, 1998 
Journal Title
 Korean Journal of Biological Sciences 
ISSN
 1226-5071 
Issue Date
1998
Keywords
Glutamate dehydrogenase ; Distribution ; Monoclonal antibodies
Abstract
Glutamate dehydrogenase (GDH) is one of the main enzymes involved in the formation and metabolism of the neurotransmitter glutamate. In the present study, we investigated the distribution of the GDH‐immunoreactive cells in the rat brain using monoclonal antibodies against bovine brain GDH isoprotein. GDH‐immunoreactive cell were distributed in the basal ganglia, thalamus and the nuclei belong to substantia innominata, and its connecting area, subthalamic nucleus, zona incerta, and substantia nigra. We could see GDH‐immunoreactive cells in the hippocampus, septal nuclei associated with the limbic system, the anterior thalamic nuclei connecting between the hypothalamus and limbic system, and its associated structures, amygdaloid nuclear complex, the dorsal raphe and median raphe nuclei and the reticular formation of the midbrain. The GDH‐immunoreactive cells were shown in the pyramidal neurons of the cerebral cortex, the Purkinje cells of the cerebella cortex, their associated structures, ventral thalamic nuclei and the reticular thalamic nuclei that seem to function as neural conduction in the thalamus.
Full Text
https://www.tandfonline.com/doi/abs/10.1080/12265071.1998.9647392
DOI
10.1080/12265071.1998.9647392
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176916
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