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혈청학적 Helicobacter pylori IgG 항체 면역검사법의 임상적 유용성: 6 가지 kit의 비교 평가

Other Titles
 Clinical Usefulness of Helicobacter pylori IgG Ab Assay: Comparison of Six Commercial Kits 
Authors
 용동은  ;  이혁민  ;  김현숙  ;  이준구  ;  이용찬 
Citation
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.18(3) : 447-451, 1998 
Journal Title
 Korean Journal of Clinical Pathology (대한임상병리학회지) 
ISSN
 1015-6445 
Issue Date
1998
Abstract
Background :The diagnostic significance of the serological detection of antibodies to Helicobacter pylori (H. pylori) has been reported by many investigators. But the comparison data between the various serological tilts were not established in Korea. Method :Forty nine patients with upper gastrointestinal symptoms were studied from June 1997 to September 1997 in Yonsei University College of Medicine, Severance hospital Endoscopic gastric biopsy specimens were obtained for microscopic examination of the bacteria and rapid unease test (CLO test) The sera of these patients were obtained for the serological test at the same time. The six commercial tilts (Cobas Core Ⅱ,G,A,P test IgG, PYLORAGEN, Quick Vue, BIOCARD Helicobacter pylori IgG, EZ-H. P.) for the detection H. pylori antibodies were evaluated for diagnosis and screening of H. pylori infection. Result :Sensitivities for the slut tilts were from 71% to 96%, specificities were from 24% to 71%, positive predictive values were from 68% to 81%, negative predictive values were from 60% to 80%, respectively There were statistically significant differences in four groups, between G.A.P test anti Cobas Core, G.A.P test and PYLORAGEN, Quick Vue anti Cobas Core, Quick Vue and PYLORAGEN. Conclusion :Sensitivities and specificities obtained in different studies revealed as great differences in the results with the same kits as between the results obtained with different tilts in the same study. So, the serologic method alone for the diagnosis of H. pylori infection is not recommended. But in the screening of H. pylori infection, it can be used, because sensitivities and negative predictive values are relatively high.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176894
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