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Meta-analysis를 이용한 UVB 조사량에 따른 피부암 발생 위해도의 예측 연구

Other Titles
 Prediction of the risk of skin cancer caused by UVB radiation exposure using a method of meta-analysis 
Authors
 신동천  ;  이종태  ;  양지연 
Citation
 Korean Journal of Preventive Medicine (예방의학회지), Vol.31(1) : 91-103, 1998 
Journal Title
 Korean Journal of Preventive Medicine (예방의학회지) 
ISSN
 0254-5985 
Issue Date
1998
Abstract
Under experimental conditions, UVB radiation, a type of ultra violet radiation, has shown to relate with the occurrence of skin erythema (sun-burn) in human and skin cancer in experimental animal. Cumulative exposure to UVB is also believed to be at least partly responsible for the "aging" process of the skin in human. It has also been observed to have an effect of altering DNA (deoxyribonucleic acid). UVB radiation is both an initiator and a promotor of non-melanoma skin cancer. Meta-analysis is a new discipline that critically reviews and statistically combines the results of previous researches. A recent review of meta-analysis in the field of public health emphasized its growing importance. Using a meta-analysis in this study, we explored more reliable dose-response relationships between UVB radiation and skin cancer incidence. We estimated skin cancer incidence using measured UVB radiation dose at a local area of Seoul (Shin chon-dong). The studies showing the dose-response relationships between UVB radiation and non-melanoma skin cancer incidence were searched and selected for a meta-analysis. The data for 7 reported epidemiological studies of three counties (USA, England, Australia) were pooled to estimated the risk. We estimated rate of incidence change of skin cancer using pooled data by meta-analysis method, and exponential and power models. Using either model, the regression coefficients for UVB did not differ significantly by gender and age. In each analysis of variance, non-melanoma skin cancer incidence after removing the gender and age and UVB effects was significant (p>0.01). The coefficients for UVB dose were estimated 2.07×10-6 by the exponential model and 2.49 by the power model. At a local area of Seoul (Shin chon-dong), BAF value were estimated 1.90 and 2.51 by the exponential and power model, respectively. The estimated BAF value were increased statistical power than that of primary studies that using a meta-analysis method.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소) > 1. Journal Papers
Yonsei Authors
Shin, Dong Chun(신동천) ORCID logo https://orcid.org/0000-0003-4252-2280
Yang, Ji Yeon(양지연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176893
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