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기능성 소화불량증 환자에서 Helicobacter pylori의 유형에 따른 위 조직학적 소견 및 혈청 위 펩티드 농도

Other Titles
 Gastric Histopathology and Serum Levels of Gastric Peptides according to Types of Helicobacter Pylori in Patients with Functional Dyspepsia 
 김경철  ;  박효진  ;  윤상애  ;  이귀순  ;  정준근  ;  이관식  ;  이상인  ;  박인서 
 Korean Journal of Gastrointestinal Endoscopy (대한소화기내시경학회지), Vol.18(1) : 11-20, 1998 
Journal Title
Korean Journal of Gastrointestinal Endoscopy(대한소화기내시경학회지)
Issue Date
Background/Aims: Clinical isolates of Helicobacter pylori(H. pylori) can be divided into at least two major types. Type I bacteria express VacA(vacuolating cytotoxin) and CagA(cytotoxin-associated antigen), type II bacteria do not exp~ress VacA or CagA. The purpose of this study is to evaluate the changes of gastric histology and serum level of gastric peptides(gastrin and pepsinogen) according to the bacteriological types in H. pylori infection. Methods: In patients with H. pylori-positive functional dyspepsia, we classified the type of infection serologically by detecting IgG antibodies to CagA and VacA. Each patient was also evaluated for the degree of gastric inflammation and serum concentrations of gastrin and pepsinogen(PG). IgG antibodies to these proteins and concentrations of gastrin and PG were detected by using a immuno-blot kit and a radioimmunoassay kit, respectively, from the sera of each patient. From endoscopically biopsied antral specimens, the degree of gastric inflammation was evaluated by scoring inflammatory changes.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
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