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간암 환자에서 예후인자를 통한 생존기간의 예측

Other Titles
 Prediction of Life-expectancy for Patients with Hepatocellular Carcinoma Based on Prognostic Factors 
Authors
 염창환  ;  심재용  ;  이혜리  ;  홍영선 
Citation
 Korean Journal of Hospice and Palliative Care (한국호스피스완화의료학회지), Vol.1(1) : 30-38, 1998 
Journal Title
 Korean Journal of Hospice and Palliative Care (한국호스피스완화의료학회지) 
ISSN
 1229-1285 
Issue Date
1998
Abstract
Background : Hepatocellular carcinomoma is the 3rd most common malignancy and the 2nd most common cause of death in Korea. The prediction of life-expectancy in terminal cancer patients is a major problem for patients, families, and physicians. We would like to investigate the prognostic factors of hepatocellular carcinoma, and therefore contribute to the prediction of the survival time of patients with hepatocellular carcinoma. Methods : A total of 91 patents(male 73, female 18) with hepatocellular carcinoma who were admitted to the hospital between January and June 1995 were entered into the study, and data were collected prospectively on 28 clinical parameters through medical obligation record. We surveyed an obligation and local district office records, and confirmed the surivival of patients till July, 1996. Using Cox-proportional hazard model, give the significant variables related to survival. These determined prognostic factors. Life regressional analysis was used, there were calculated predicted survival day based on combinations of the significant prognostic factors. Results : 1) Out of 91 patients, 73 were male, and 18 were female. The mean age was 56.7±10.6 years. During the study, except for 16 patients who could not follow up, out of 75 patients, the number of deaths was 57(76%) and the number of survivals was 18(24%). 2) Out of the 28 clinical parameters, the prognostic factors related to reduced survival rate were prothrombin time <40%(relative risk:10.8), weight loss(RR:4.4), past history of hypertension(RR:3.2), ascites(RR:2.8), hypocalcemia(RR:2.5) (P<0.001). 3) Out of five factors, the survival day is 1.7 in all of five, 4.2∼10.0 in four, 10.4∼41.9 in three, 29.5∼118.1 in two, 124.0∼296.6 in one, 724.0 in none. Conclusion : In hepatocellular carcinoma we found that the prognostic factors related to reduce survival rate were prolonged prothrombin time(<40%), weight loss, past history of hypertension, ascites, and hypocalcemia(<8.7mg/dl). The five prognostic factors enabled the prediction of life-expectancy in patents with hepatocellular carcinoma and may assist in managing patients with hepatocellular carcinoma.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Hye Ree(이혜리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176864
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