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미세변화형 신증에서 cyclosporine A 투여 후 혈액 및 요중 endothelin-1치의 변화

Other Titles
 Effect of Cyclosporine A on Plasma and Urine Levels of Endothelin-1 in Steroid Dependent Minimal Change Nephrotic Syndrome 
 김제우  ;  김지홍  ;  이진성  ;  김병길  ;  김현숙 
 Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지), Vol.2(1) : 20-25, 1998 
Journal Title
 Journal of the Korean Society of Pediatric Nephrology (대한소아신장학회지) 
Issue Date
Purpose : It has been reported that endothelin-1 can be associated with the development of cyclosporine A nephrotoxicity. Levels of endothelin-1 was assayed to determine the effect of cyclosporine A on the plasma and urine levels of this peptide. Method : Nine patients who were less than 15 years of age and were also diagnosed as steroid dependent minimal change nephrotic syndrome were included in this study. Assay of endothelin-1 was done before and 3 months after cyclosporine A treatment. The mean age of the patients was 8.3 ±4.6 years. Result : There was no significant differences in the plasma levels of endothelin-1 before and after 3 months of cyclosporine A treatment (3.22±0.39 pg/mL vs. 3.84±1.52 pg/mL, P=0.64). Also there was no changes in the urine levels of endothelin-1 (21.8 ± 5.8 pg/mL vs. 20.3 ±3.1 pg/mL, P=0.30). Conclusion : No significant changes of endothelin-1 levels were found with 3 months of cyclosporine A treatment. Further studies with longer durations will help clarifying the effect.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyon Suk(김현숙) ORCID logo https://orcid.org/0000-0001-5662-7740
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