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Treatment of Suprachoroidal Hemorrhage with Tissue Plasminogen Activator

Authors
 Kwon O.W.  ;  Kang S.J.b  ;  Lee J.B.  ;  Lee S.C.  ;  Yoon Y.D.  ;  Oh J.H. 
Citation
 OPHTHALMOLOGICA, Vol.212(2) : 120-125, 1998 
Journal Title
 OPHTHALMOLOGICA 
ISSN
 0030-3755 
Issue Date
1998
MeSH
Administration, Topical ; Animals ; Choroid Hemorrhage/blood ; Choroid Hemorrhage/drug therapy* ; Choroid Hemorrhage/pathology ; Dose-Response Relationship, Drug ; Follow-Up Studies ; Photoreceptor Cells/drug effects ; Photoreceptor Cells/pathology ; Plasminogen Activators/therapeutic use* ; Rabbits ; Random Allocation ; Surgical Sponges ; Thrombolytic Therapy* ; Tissue Plasminogen Activator/therapeutic use* ; Treatment Outcome
Abstract
We evaluated the efficacy of tissue plasminogen activator in treating experimental suprachoroidal hemorrhage. Suprachoroidal hemorrhage was created in 30 white rabbit eyes by implanting four pieces of small, exogenously formed blood coagula into the suprachoroidal space. Animals were randomized for treatment with a surgical sponge soaked in 25, 50, or 75 microg of tissue plasminogen activator (tPA) or balanced salt solution (BSS) as a control. The time when initiation and completion of clot dissolution occurred was established, and histological examination was performed to assess damage. Clot dissolution started within 30 min in the 50- and 75-microg tPA group, whereas it took 2.75 days in the control group; complete dissolution of blood clots took 4.5 h in the 75-microg tPA group and 14 days in the control group. Histological examination revealed a minimal change in photoreceptors within 6 h after treatment with 75 microg tPA. Treatment of suprachoroidal hemorrhage with tPA seems to be effective, but further investigations for determining the effective and nontoxic dose are required.
Full Text
http://www.karger.com/Article/FullText/27295
DOI
10.1159/000027295
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176744
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