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Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita

Authors
 Heun Jung Cho  ;  Il Joo Lee  ;  Soo Chan Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.39(4) : 339-344, 1998 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1998
MeSH
Adult ; Autoantibodies/classification* ; Complement System Proteins/immunology* ; Epidermolysis Bullosa Acquisita/immunology* ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G/classification* ; Male ; Middle Aged
Abstract
Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
Files in This Item:
T199801825.pdf Download
DOI
10.3349/ymj.1998.39.4.339
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176607
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