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Interleukin-1 beta, -6 and interferon-gamma productions in patients undergoing continuous ambulatory peritoneal dialysis

 Kyu Hun Choi  ;  In Hee Lee  ;  Sug Kyun Shin  ;  Hyun Jin Noh  ;  Shin Wook Kang  ;  Ho Young Lee  ;  Dae Suk Han 
 YONSEI MEDICAL JOURNAL, Vol.39(3) : 240-246, 1998 
Journal Title
Issue Date
Adult ; Cells, Cultured ; Female ; Humans ; Interferon-gamma/biosynthesis* ; Interleukin-1/biosynthesis* ; Interleukin-6/biosynthesis* ; Male ; Middle Aged ; Monocytes/metabolism ; Parathyroid Hormone/blood ; Peritoneal Dialysis, Continuous Ambulatory* ; Serum Albumin/analysis
In order to investigate cytokine productions in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), we studied the production of interleukin (IL)-1 β, -6 and interferon (IFN)-γ by cultured peripheral blood mononuclear cells (PBMC) in peritonitis-free CAPD patients. The correlation of cytokine production with plasma parathyroid hormone (PTH) and albumin levels was also evaluated. While the release of IL-1 β was not markedly different from controls release of IL-6 from 24-hour cultured PBMCs was significantly greater than that of controls, (Mean ± S.D., IL-6: 2186.8 ± 1217.9 pg/ml, vs 1516.3 ± 767.9, P <0.05). The addition of lipopolysaccharide (LPS, 10 µg/ml, significantly stimulated IL-1 β and -6 production of PBMCs in CAPD patients and controls, compared to an unstimulated condition. The LPS-induced IL-1 β production was also not markedly different from controls, whereas LPS-induced IL-6 production was significantly higher than controls (IL-6: 13,220.7 ± 7177.4 vs 7411.4 ± 1236.9, P <0.05). However, the percentage increases of IL-6 production stimulated with LPS in CAPD patients were not significantly different from controls (p > 0.05). No difference of baseline IFN-γ was detected between CAPD patients controls, but phytohemagglutinin (PHA, 10 µg/ml)-stimulated IFN-γ release was significantly higher in CAPD patients than controls (2425.9 ± 1565.0 pg/ml vs 1364.0 ± 755.1, P <0.05). There was no significant correlation between PTH and, IL-1 β, serum albumin level and LPS-stimulated IL-6 production (r = 0.54, P <0.05). In conclusion, CAPD seems to partly induce activation of PBMCs with an enhanced release of IL-6 and IFN-γ, and CAPD patients with higher serum albumin levels tend to show higher IL-6 production in immune response.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
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