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Interleukin-1 beta, -6 and interferon-gamma productions in patients undergoing continuous ambulatory peritoneal dialysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 최규헌 | - |
dc.date.accessioned | 2020-07-02T17:06:41Z | - |
dc.date.available | 2020-07-02T17:06:41Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176597 | - |
dc.description.abstract | In order to investigate cytokine productions in patients undergoing continuous ambulatory peritoneal dialysis (CAPD), we studied the production of interleukin (IL)-1 β, -6 and interferon (IFN)-γ by cultured peripheral blood mononuclear cells (PBMC) in peritonitis-free CAPD patients. The correlation of cytokine production with plasma parathyroid hormone (PTH) and albumin levels was also evaluated. While the release of IL-1 β was not markedly different from controls release of IL-6 from 24-hour cultured PBMCs was significantly greater than that of controls, (Mean ± S.D., IL-6: 2186.8 ± 1217.9 pg/ml, vs 1516.3 ± 767.9, P <0.05). The addition of lipopolysaccharide (LPS, 10 µg/ml, significantly stimulated IL-1 β and -6 production of PBMCs in CAPD patients and controls, compared to an unstimulated condition. The LPS-induced IL-1 β production was also not markedly different from controls, whereas LPS-induced IL-6 production was significantly higher than controls (IL-6: 13,220.7 ± 7177.4 vs 7411.4 ± 1236.9, P <0.05). However, the percentage increases of IL-6 production stimulated with LPS in CAPD patients were not significantly different from controls (p > 0.05). No difference of baseline IFN-γ was detected between CAPD patients controls, but phytohemagglutinin (PHA, 10 µg/ml)-stimulated IFN-γ release was significantly higher in CAPD patients than controls (2425.9 ± 1565.0 pg/ml vs 1364.0 ± 755.1, P <0.05). There was no significant correlation between PTH and, IL-1 β, serum albumin level and LPS-stimulated IL-6 production (r = 0.54, P <0.05). In conclusion, CAPD seems to partly induce activation of PBMCs with an enhanced release of IL-6 and IFN-γ, and CAPD patients with higher serum albumin levels tend to show higher IL-6 production in immune response. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interferon-gamma/biosynthesis* | - |
dc.subject.MESH | Interleukin-1/biosynthesis* | - |
dc.subject.MESH | Interleukin-6/biosynthesis* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes/metabolism | - |
dc.subject.MESH | Parathyroid Hormone/blood | - |
dc.subject.MESH | Peritoneal Dialysis, Continuous Ambulatory* | - |
dc.subject.MESH | Serum Albumin/analysis | - |
dc.title | Interleukin-1 beta, -6 and interferon-gamma productions in patients undergoing continuous ambulatory peritoneal dialysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | In Hee Lee | - |
dc.contributor.googleauthor | Sug Kyun Shin | - |
dc.contributor.googleauthor | Hyun Jin Noh | - |
dc.contributor.googleauthor | Shin Wook Kang | - |
dc.contributor.googleauthor | Ho Young Lee | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.identifier.doi | 10.3349/ymj.1998.39.3.240 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A04043 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 9664829 | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 최규헌 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 240 | - |
dc.citation.endPage | 246 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.39(3) : 240-246, 1998 | - |
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