0 24

Cited 0 times in

Does delayed operation for pediatric ureteropelvic junction obstruction cause histopathological changes?

Authors
 SANG WON HAN  ;  SEUNG EON LEE  ;  JANG HWAN KIM  ;  HYEON JOO JEONG  ;  KOON HO RHA  ;  SEUNG KANG CHOI 
Citation
 JOURNAL OF UROLOGY, Vol.160(3Pt2) : 984-989, 1998 
Journal Title
 JOURNAL OF UROLOGY 
ISSN
 0022-5347 
Issue Date
1998
MeSH
Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Kidney Pelvis/pathology* ; Kidney Pelvis/surgery* ; Male ; Time Factors ; Ureteral Obstruction/pathology* ; Ureteral Obstruction/surgery*
Abstract
PURPOSE: We studied histopathological changes in kidneys with demonstrable ureteropelvic junction obstruction in relation to patient age, differential renal function and urinary tract infection. MATERIALS AND METHODS: Renal biopsy was performed in 42 children (44 kidneys) with a mean age of 3 years 6 months who underwent open pyeloplasty due to ureteropelvic junction obstruction. Each specimen was examined for reversible inflammatory cell infiltration and irreversible change, including interstitial fibrosis, arteriolar thickening and glomerular sclerosis. Each pathological finding was scored 0 to 3 in increasing grades of severity, and correlated with patient age, differential renal function and history of urinary tract infection. RESULTS: Of the 44 kidneys 20 (45%) had irreversible change. Correlation study revealed no association between patient age and histological findings, and there was no statistically significant difference in any histopathological category regardless of age. Differential renal function correlated with inflammatory cell infiltration and interstitial fibrosis. There were significantly worse histopathology scores in all categories when differential renal function was less than 30 versus 40% or greater. Interstitial fibrosis was significantly worse in the 30 to 40% group than in the greater than 40% group. The histopathological score of interstitial fibrosis was significantly higher in patients with than without urinary tract infection. CONCLUSIONS: Early correction in infants with ureteropelvic junction obstruction may not be necessary when initial differential renal function is greater than 40%. However, any decrease in differential renal function or recurrent urinary tract infections despite antibiotic prophylaxis warrant surgical correction of obstruction.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534701626764
DOI
10.1016/S0022-5347(01)62676-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jang Hwan(김장환) ORCID logo https://orcid.org/0000-0002-9056-7072
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176589
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links