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위절제를 시행한 위암환자 2603예의 생존율 및 예후인자 분석

Other Titles
 Results after a gastrectomy of 2,603 patients with gastric cancer: Analysis of survival rate and prognostic factor 
Authors
 노성훈  ;  류창학  ;  김용일  ;  김충배  ;  민진식  ;  이경식 
Citation
 Journal of the Korean Surgical Society (대한외과학회지), Vol.55(2) : 206-213, 1998 
Journal Title
 Journal of the Korean Surgical Society (대한외과학회지) 
ISSN
 1226-0053 
Issue Date
1998
Abstract
A retrospective study of 2,603 patients with gastric cancer who underwent a gastric resection at Yonsei University Hospital from 1987 to 1994 was performed to evaluate the clinicopathological characteristics and survival rates of patients with gastric cancer. There were 1721 males and 882 females (ratio=2:1) with a mean age of 54 years (range=22∼85 years). All patients underwent gastric resection with curative intent, but 199 patients (7.6%) had a palliative resection. The types of operations were a subtotal gastrectomy in 1,917 patients (73.695) and a total gastrectomy in 686 patients (26.4%). A D2 or a more extended lymph-node dissection was performed in 2530 patients (97.2%), and only 73 patients (2.8%) had less extensive surgery. The postoperative mortality was 0.9%. The mean diameter of a tumor was 5.6 cm. The most common location of a tumor was the lower third of the stomach (49.4%). Borrmann type Ⅲ(64.7%) was the most common gross type. The major histologic type was a tubular adenocarcinoma (76.3%). The overall 5-year survival rate was 66.5%. The 5-year survival rates according to the stage were 94.3% in IA, 90.5% in IB, 76.6% in Ⅱ, 60.1% in ⅢA, 38.7% in ⅢB, and 12.9% in Ⅳ. In the univariate analysis, poor survival was closely related to increasing age, tumor location in the upper one third, larger tumor size, Borrmann type Ⅳ tumors, increasing pT and pN classifications, an advanced tumor stage, and perforance of a total gastrectomy. The multivariate analysis revealed that distant metastasis, lymph-node metastasis, depth of invasion, gross type, age, and type of resection were significant prognostic factors. In conclusion, the prognosis for gastric cancer after a gastrectomy has remarkably improved, and the most significant prognostic factors were distant metastasis, lymph node metastasis, and depth of invasion. Therefore, early diagnosis of gastric cancer and aggressive multimodal therapy, especially in patients with stage ⅢB and Ⅳ tumors might improve the quality of life and the survival of the patients with gastric cancer.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176576
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