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Epstein-Barr virus and gastrointestinal lymphomas in Korea

Authors
 Woo Ick Yang  ;  Min Sun Cho  ;  Yasuhiko Tomita  ;  Masahiko Ohsawa  ;  Katsuyuki Aozasa 
Citation
 YONSEI MEDICAL JOURNAL, Vol.39(3) : 268-276, 1998 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
1998
MeSH
Gastrointestinal Neoplasms/pathology ; Gastrointestinal Neoplasms/virology* ; Genome, Viral ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification* ; Humans ; In Situ Hybridization ; Korea ; Lymphoma/pathology ; Lymphoma/virology* ; Polymerase Chain Reaction
Abstract
To analyze the association of Epstein-Barr virus (EBV) with gastrointestinal non-Hodgkin's lymphomas arising in immunocompetent patients, 56 consecutive cases of gastrointestinal lymphomas (B-cell: 52-cases, T-cell: 3 cases, T/NK-cell: 1 case) occurring in the stomach (33 cases), intestine (22 cases) and esophagus (1 case) were investigated for the presence of EBV using polymerase chain reaction analysis as a screening method followed by EBER-1 RNA and DNA in situ hybridization (ISH) and immunohistochemistry for the expression of latent membrane protein 1 (LMP-1). Forty-seven cases demonstrated extractable DNA and EBV DNA was detected only in 4 cases. Among the, RNA (EBER-1) and DNA ISH analysis confirmed the presence of the EBV genome in tumor cells in 3 cases (T/NK-cell lymphoma of ileum, gastric high-grade B-cell lymphoma of mucosa-associated lymphoid tissue, gastric diffuse large B-cell lymphoma). Only the T/NK cell lymphoma showed diffuse positivity of tumor cells while 2 gastric B-cell lymphomas demonstrated a scattered positive reaction and no cases expressed LMP-1. Nine cases without extractable DNA by the PCR method showed no nuclear signal by EBER-1 ISH. These findings suggest that most sporadic primary gastrointestinal lymphomas in Korea are not associated with EBV.
Files in This Item:
T199801506.pdf Download
DOI
10.3349/ymj.1998.39.3.268
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176492
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