Cited 9 times in
Epstein-Barr virus and gastrointestinal lymphomas in Korea
DC Field | Value | Language |
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dc.contributor.author | 양우익 | - |
dc.date.accessioned | 2020-07-02T16:58:16Z | - |
dc.date.available | 2020-07-02T16:58:16Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176492 | - |
dc.description.abstract | To analyze the association of Epstein-Barr virus (EBV) with gastrointestinal non-Hodgkin's lymphomas arising in immunocompetent patients, 56 consecutive cases of gastrointestinal lymphomas (B-cell: 52-cases, T-cell: 3 cases, T/NK-cell: 1 case) occurring in the stomach (33 cases), intestine (22 cases) and esophagus (1 case) were investigated for the presence of EBV using polymerase chain reaction analysis as a screening method followed by EBER-1 RNA and DNA in situ hybridization (ISH) and immunohistochemistry for the expression of latent membrane protein 1 (LMP-1). Forty-seven cases demonstrated extractable DNA and EBV DNA was detected only in 4 cases. Among the, RNA (EBER-1) and DNA ISH analysis confirmed the presence of the EBV genome in tumor cells in 3 cases (T/NK-cell lymphoma of ileum, gastric high-grade B-cell lymphoma of mucosa-associated lymphoid tissue, gastric diffuse large B-cell lymphoma). Only the T/NK cell lymphoma showed diffuse positivity of tumor cells while 2 gastric B-cell lymphomas demonstrated a scattered positive reaction and no cases expressed LMP-1. Nine cases without extractable DNA by the PCR method showed no nuclear signal by EBER-1 ISH. These findings suggest that most sporadic primary gastrointestinal lymphomas in Korea are not associated with EBV. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Gastrointestinal Neoplasms/pathology | - |
dc.subject.MESH | Gastrointestinal Neoplasms/virology* | - |
dc.subject.MESH | Genome, Viral | - |
dc.subject.MESH | Herpesvirus 4, Human/genetics | - |
dc.subject.MESH | Herpesvirus 4, Human/isolation & purification* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Lymphoma/pathology | - |
dc.subject.MESH | Lymphoma/virology* | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.title | Epstein-Barr virus and gastrointestinal lymphomas in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Min Sun Cho | - |
dc.contributor.googleauthor | Yasuhiko Tomita | - |
dc.contributor.googleauthor | Masahiko Ohsawa | - |
dc.contributor.googleauthor | Katsuyuki Aozasa | - |
dc.identifier.doi | 10.3349/ymj.1998.39.3.268 | - |
dc.contributor.localId | A02300 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 9664833 | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 268 | - |
dc.citation.endPage | 276 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.39(3) : 268-276, 1998 | - |
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