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Midazolam의 절제한 기니픽 기관평활근 이완에 미치는 Flumazenil 및 Verapamil의 영향

Other Titles
 The Effects of FlumaBenil and Verapamil on the Relaxation of Midazolam in Isolated Guinea-pig Tracheal Smooth Muscle 
 고신옥  ;  김기준  ;  김원옥  ;  조성민  ;  김명옥 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.34(1) : 1-4, 1998 
Journal Title
 Journal of Korean Society of Anesthesiologist (대한마취과학회지) 
Issue Date
Background: Midazolam relaxes airway smooth muscle. The aim of this study is to evaluate the influence of flumazenil or verapamil on the relaxation effects of midazolam in tracheal smooth muscle of guinea pig. Methods: After isolating guinea-pig tracheal preparations, the maximal tracheal tones were induced by 2 X 10-7 M carbachol. When tracheal tones stabilized, midazolam was added cumulatively(10-6, 3 X 10-6, 10-5, 3 X 10-5, 10-4 M, n=14) with or without flumazenil(10-6 M, n=15) and verapamil(10-5 M, n=13) to obtain the concentration-relaxation curves, and then the ED50 and ED95 calculated. Results: Midazolam decreased maximal tracheal smooth muscle tones in concentration-dependent manners. Pretreatment with flumazenil had no effect on the midazolam-induced relaxation. Verapamil enhanced the relaxation effect of midazolam. Conclusions: Midazolam relaxes airway smooth muscle and has synergistic effect with calcium channel blocker, verapamil.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Shin Ok(고신옥)
Kim, Won Oak(김원옥)
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