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위암에서 위전절제술시 비장합병절제의 의의

Other Titles
 Effectiveness of Combined Resection of Spleen in Total Gastrectomy for Gastric Cancer 
Authors
 김완수  ;  노성훈  ;  류창학  ;  김용일  ;  김충배  ;  이경식  ;  민진식  ;  김완식 
Citation
 Journal of the Korean Surgical Society (대한외과학회지), Vol.54(3) : 363-368, 1998 
Journal Title
 Journal of the Korean Surgical Society (대한외과학회지) 
ISSN
 1226-0053 
Issue Date
1998
Abstract
Combined resection of the spleen during total gastrectomy for gastric cancer is usually performed to remove the lymph nodes adequately and thereby achieving surgical radicality. However there is still controversy whether a total gastrectomy combined with a splenectomy can improve the survival rate. The authors retrospectively analyzed 557 gastric cancer patients, who underwent total gastrectomy at the Department of Surgery of Yonsei University during the 7-year period between 1987 and 1993, in order to investigate the influence of combined resection of the spleen upon the patients'survival. The patients were followed until March 1996, and the rate of follow up was 90.6%. The number of cases in which the spleen was saved was 101 (the spleen conservation group, SC) and the number of cases in which the spleen was resected was 431(the spleen resection group, SR). Twenty-five cases were excluded due to incomplete data. Among the 431 cases for whom splenectomy was done, 343 were cases in which spleen was the only organ removed other than the stomach (SOR). For the other 88 cases, at least 1 more organs were resected along with the stomach and the spleen(Sp + combined). There were no significant differences in the clinical characteristics such as age, sex ratio, tumor size, depth of invasion, nodal stage, TNM stage and histological type between SC and SOR group. In terms of the nodes removed during operation, there was significant difference between the SC and the SOR groups. Also, the Sp+combined group showed significant differences in terms of tumor size, depth, nodal stage, TNM stage, and removed nodes. The overall 5-yr survival rate for the spleen conservation group(SC,N=101) was 61.2% and the survival rates according to TNM stage were 94.0% for stage Ⅰ, 94.1% for stage Ⅱ, 30.0% for Ⅲ. and 0.0% for stage IV The overall 5-yr survival rate for the 343 patients with splenectomy(SOR) was 51.9%, and the survival rates according to WM stages were 88.7% for stage Ⅰ,57.0% for Ⅱ,44.0% for Ⅲ, and 10.8% for stage Ⅳ. The overall 5-yr survival rate for the 431 patients with splenectomies or with splenectomies and multiple organ resection(SR) was 48.2%, and the survival rates according to the stages were 88.2% for stage Ⅰ, 60.2% for Ⅱ, 41.5% for Ⅲ, and 6.8% for stage IV. The overall 5-yr survival rate was higher in SC group than in the SOR or the SR groups, but there was no statistical significance to this difference (p>0.05).In a compared according to the TNM stage, the SC group showed better survival rates in the relatively early stages (Ⅰ,Ⅱ) than the SOR or the SR groups did; in advanced stages (Ⅲ,Ⅳ), the SOR and the SR groups showed better survival rates than the SC group. However, there was no statistically significant differences in survival among the three groups. These results suggest that during a total gastrectomy, it may be better to save the spleen in early stages of gastric cancer and that it may be better to resect the spleen for adequate lymphadenectomy in grossly advanced stages. To identify statistical difference in survival, it might be necessary to perform a randomized prospective study.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176470
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