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c-erbB-2 oncoprotein assay in ovarian carcinoma and its clinical correlation with prognostic factors

Authors
 Young Tae Kim  ;  Jae Wook Kim  ;  Jung Woon Lee 
Citation
 CANCER LETTERS, Vol.132(1~2) : 91-97, 1998 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1998
MeSH
Adult ; Aged ; Carcinoma/metabolism* ; Carcinoma/pathology ; Carcinoma/surgery ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms/metabolism* ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Pelvis ; Prognosis ; Receptor, ErbB-2/analysis*
Abstract
Overexpression of the c-erbB-2 oncoprotein has been detected in human adenocarcinoma of the breast, cervix and salivary gland, in all of which an association between the overexpression of the c-erbB-2 and a poor prognosis of the disease has been reported. However, the prognostic role of c-erbB-2 oncoprotein in ovarian carcinoma remains controversial. We measured c-erbB-2 oncoprotein with an enzyme-linked immunosorbent assay (ELISA). Patients with invasive ovarian cancer were found to have significantly higher median c-erbB-2 oncoprotein expression than patients with either benign ovarian cyst (P = 0.002) or control groups (P = 0.001). Overexpression of c-erbB-2 oncoprotein was found in seven (21.9%) of 32 epithelial ovarian cancers. Our results suggest that quantitative analysis of c-erbB-2 oncoprotein may be used to define the prognostic significance of ovarian carcinoma.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383598001621
DOI
10.1016/s0304-3835(98)00162-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176406
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