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HLA class II allele associations in Korean patients with pemphigus

Authors
 C.W. Lee  ;  H.Y. Yang  ;  S-C. Kim  ;  J.H. Jung  ;  J.J. Hwang 
Citation
 DERMATOLOGY, Vol.197(4) : 349-352, 1998 
Journal Title
 DERMATOLOGY 
ISSN
 1018-8665 
Issue Date
1998
MeSH
Alleles ; Gene Frequency ; Genes, MHC Class II/genetics* ; Genotype ; HLA-DQ Antigens/genetics ; HLA-DQ alpha-Chains ; HLA-DQ beta-Chains ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Korea/epidemiology ; Pemphigus/epidemiology ; Pemphigus/genetics*
Abstract
BACKGROUND: Studies at the population level have demonstrated associations between pemphigus (pemphigus vulgaris, PV, and pemphigus foliaceus, PF) and particular HLA haplotypes, which suggests that there may be a genetic predisposition for the disease. OBJECTIVE/METHODS: The aim of the present study was to examine the distribution/frequency pattern of HLA class II alleles (DRB1, DQA1 and DQB1) from a group of 30 Korean patients with pemphigus (15 PV and 15 PF) by PCR amplification with sequence-specific primers. RESULTS: In PV, the frequency of DRB1*01 allele was found to be significantly high (pc = 0.0014); in PF, DRB1*01, DQA1*0302 and DQB1*0603 alleles showed positive associations with statistical significances (pc = 0.0002, 0.0007 and 0.0067, respectively), when compared with those found in Korean controls. CONCLUSIONS: In this small-sample study, findings of allelic frequencies among Korean patients with pemphigus are somewhat different from those found in other populations.
Full Text
https://www.karger.com/Article/FullText/18030#
DOI
10.1159/000018030
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176384
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