0 232

Cited 21 times in

HLA class II allele associations in Korean patients with pemphigus

DC Field Value Language
dc.contributor.author김수찬-
dc.date.accessioned2020-07-02T16:49:46Z-
dc.date.available2020-07-02T16:49:46Z-
dc.date.issued1998-
dc.identifier.issn1018-8665-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176384-
dc.description.abstractBACKGROUND: Studies at the population level have demonstrated associations between pemphigus (pemphigus vulgaris, PV, and pemphigus foliaceus, PF) and particular HLA haplotypes, which suggests that there may be a genetic predisposition for the disease. OBJECTIVE/METHODS: The aim of the present study was to examine the distribution/frequency pattern of HLA class II alleles (DRB1, DQA1 and DQB1) from a group of 30 Korean patients with pemphigus (15 PV and 15 PF) by PCR amplification with sequence-specific primers. RESULTS: In PV, the frequency of DRB1*01 allele was found to be significantly high (pc = 0.0014); in PF, DRB1*01, DQA1*0302 and DQB1*0603 alleles showed positive associations with statistical significances (pc = 0.0002, 0.0007 and 0.0067, respectively), when compared with those found in Korean controls. CONCLUSIONS: In this small-sample study, findings of allelic frequencies among Korean patients with pemphigus are somewhat different from those found in other populations.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherKarger-
dc.relation.isPartOfDERMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlleles-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenes, MHC Class II/genetics*-
dc.subject.MESHGenotype-
dc.subject.MESHHLA-DQ Antigens/genetics-
dc.subject.MESHHLA-DQ alpha-Chains-
dc.subject.MESHHLA-DQ beta-Chains-
dc.subject.MESHHLA-DR Antigens/genetics-
dc.subject.MESHHLA-DRB1 Chains-
dc.subject.MESHHumans-
dc.subject.MESHKorea/epidemiology-
dc.subject.MESHPemphigus/epidemiology-
dc.subject.MESHPemphigus/genetics*-
dc.titleHLA class II allele associations in Korean patients with pemphigus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorC.W. Lee-
dc.contributor.googleauthorH.Y. Yang-
dc.contributor.googleauthorS-C. Kim-
dc.contributor.googleauthorJ.H. Jung-
dc.contributor.googleauthorJ.J. Hwang-
dc.identifier.doi10.1159/000018030-
dc.contributor.localIdA00637-
dc.relation.journalcodeJ00708-
dc.identifier.eissn1421-9832-
dc.identifier.pmid9873173-
dc.identifier.urlhttps://www.karger.com/Article/FullText/18030#-
dc.contributor.alternativeNameKim, Soo Chan-
dc.contributor.affiliatedAuthor김수찬-
dc.citation.volume197-
dc.citation.number4-
dc.citation.startPage349-
dc.citation.endPage352-
dc.identifier.bibliographicCitationDERMATOLOGY, Vol.197(4) : 349-352, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.