0 18

Cited 0 times in

Different expression patterns of MMP-2 and MMP-9 in breast cancer

Authors
 S Y Rha  ;  W I Yang  ;  J H Kim  ;  J K Roh  ;  J S Min  ;  K S Lee  ;  B S Kim  ;  H C Chung 
Citation
 ONCOLOGY REPORTS, Vol.5(4) : 875-879, 1998 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
1998
MeSH
Adult ; Aged ; Biomarkers, Tumor ; Breast Neoplasms/enzymology* ; Breast Neoplasms/pathology ; Case-Control Studies ; Collagenases/biosynthesis* ; Electrophoresis, Polyacrylamide Gel ; Enzyme Activation ; Female ; Follow-Up Studies ; Gelatinases/biosynthesis* ; Humans ; Matrix Metalloproteinase 2 ; Matrix Metalloproteinase 9 ; Metalloendopeptidases/biosynthesis* ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Tumor Cells, Cultured
Abstract
Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage.
Full Text
http://www.spandidos-publications.com/or/5/4/875
DOI
10.3892/or.5.4.875
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176383
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links