Cited 27 times in
Different expression patterns of MMP-2 and MMP-9 in breast cancer
DC Field | Value | Language |
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dc.contributor.author | 김주항 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2020-07-02T16:49:33Z | - |
dc.date.available | 2020-07-02T16:49:33Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176383 | - |
dc.description.abstract | Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | D.A. Spandidos | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Breast Neoplasms/enzymology* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Collagenases/biosynthesis* | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gelatinases/biosynthesis* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 2 | - |
dc.subject.MESH | Matrix Metalloproteinase 9 | - |
dc.subject.MESH | Metalloendopeptidases/biosynthesis* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Different expression patterns of MMP-2 and MMP-9 in breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | S Y Rha | - |
dc.contributor.googleauthor | W I Yang | - |
dc.contributor.googleauthor | J H Kim | - |
dc.contributor.googleauthor | J K Roh | - |
dc.contributor.googleauthor | J S Min | - |
dc.contributor.googleauthor | K S Lee | - |
dc.contributor.googleauthor | B S Kim | - |
dc.contributor.googleauthor | H C Chung | - |
dc.identifier.doi | 10.3892/or.5.4.875 | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 9625836 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/5/4/875 | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | 김주항 | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 라선영 | - |
dc.contributor.affiliatedAuthor | 양우익 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 5 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 875 | - |
dc.citation.endPage | 879 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.5(4) : 875-879, 1998 | - |
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