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Dopaminergic influences on the P300 abnormality in Parkinson's disease

Authors
 Young H Sohn  ;  Gyung W Kim  ;  Kyoon Huh  ;  Jin-Soo Kim 
Citation
 JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.158(1) : 83-87, 1998 
Journal Title
 JOURNAL OF THE NEUROLOGICAL SCIENCES 
ISSN
 0022-510X 
Issue Date
1998
MeSH
Acoustic Stimulation ; Aged ; Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/pharmacology* ; Antiparkinson Agents/therapeutic use ; Cholinergic Antagonists/administration & dosage ; Cholinergic Antagonists/pharmacology ; Cholinergic Antagonists/therapeutic use ; Cognition Disorders/drug therapy ; Cognition Disorders/etiology ; Cognition Disorders/physiopathology* ; Dopamine/physiology* ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/pharmacology* ; Dopamine Agonists/therapeutic use ; Drug Therapy, Combination ; Electroencephalography/drug effects* ; Event-Related Potentials, P300* ; Female ; Humans ; Levodopa/administration & dosage ; Levodopa/pharmacology* ; Levodopa/therapeutic use ; Longitudinal Studies ; Male ; Mental Processes ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Parkinson Disease/physiopathology* ; Parkinson Disease/psychology ; Reaction Time/drug effects ; Severity of Illness Index
Abstract
This study was designed to evaluate the contribution of central dopaminergic mechanisms to the P300 event-related potential (P300) abnormality in Parkinson's disease. We measured the P300 in 37 non-demented patients with Parkinson's disease (19 de novo and 18 levodopa-treated) and 15 age-matched healthy volunteers. The P300 measurement was repeated in 14 de novo patients, after 6–12 months levodopa therapy. The severity of parkinsonian symptom was assessed using the UPDRS-motor scale. De novo patients showed prolonged P300 latency compared with levodopa-treated patients, as well as healthy volunteers. The levodopa therapy for 6–12 months significantly shortened the P300 latency and reduced the UPDRS-motor examination score in de novo patients. However, the percent changes in the P300 latency were not correlated with those in the UPDRS-motor examination score. These results indicate that the central dopaminergic mechanisms apart from those responsible for motor symptoms, may contribute to the P300 abnormality in Parkinson's disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022510X98001026
DOI
10.1016/S0022-510X(98)00102-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gyung Whan(김경환) ORCID logo https://orcid.org/0000-0001-7053-4372
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176314
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