Cited 44 times in
Dopaminergic influences on the P300 abnormality in Parkinson's disease
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 손영호 | - |
dc.date.accessioned | 2020-07-02T16:43:24Z | - |
dc.date.available | 2020-07-02T16:43:24Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176314 | - |
dc.description.abstract | This study was designed to evaluate the contribution of central dopaminergic mechanisms to the P300 event-related potential (P300) abnormality in Parkinson's disease. We measured the P300 in 37 non-demented patients with Parkinson's disease (19 de novo and 18 levodopa-treated) and 15 age-matched healthy volunteers. The P300 measurement was repeated in 14 de novo patients, after 6–12 months levodopa therapy. The severity of parkinsonian symptom was assessed using the UPDRS-motor scale. De novo patients showed prolonged P300 latency compared with levodopa-treated patients, as well as healthy volunteers. The levodopa therapy for 6–12 months significantly shortened the P300 latency and reduced the UPDRS-motor examination score in de novo patients. However, the percent changes in the P300 latency were not correlated with those in the UPDRS-motor examination score. These results indicate that the central dopaminergic mechanisms apart from those responsible for motor symptoms, may contribute to the P300 abnormality in Parkinson's disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acoustic Stimulation | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antiparkinson Agents/administration & dosage | - |
dc.subject.MESH | Antiparkinson Agents/pharmacology* | - |
dc.subject.MESH | Antiparkinson Agents/therapeutic use | - |
dc.subject.MESH | Cholinergic Antagonists/administration & dosage | - |
dc.subject.MESH | Cholinergic Antagonists/pharmacology | - |
dc.subject.MESH | Cholinergic Antagonists/therapeutic use | - |
dc.subject.MESH | Cognition Disorders/drug therapy | - |
dc.subject.MESH | Cognition Disorders/etiology | - |
dc.subject.MESH | Cognition Disorders/physiopathology* | - |
dc.subject.MESH | Dopamine/physiology* | - |
dc.subject.MESH | Dopamine Agonists/administration & dosage | - |
dc.subject.MESH | Dopamine Agonists/pharmacology* | - |
dc.subject.MESH | Dopamine Agonists/therapeutic use | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Electroencephalography/drug effects* | - |
dc.subject.MESH | Event-Related Potentials, P300* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Levodopa/administration & dosage | - |
dc.subject.MESH | Levodopa/pharmacology* | - |
dc.subject.MESH | Levodopa/therapeutic use | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mental Processes | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parkinson Disease/complications | - |
dc.subject.MESH | Parkinson Disease/drug therapy | - |
dc.subject.MESH | Parkinson Disease/physiopathology* | - |
dc.subject.MESH | Parkinson Disease/psychology | - |
dc.subject.MESH | Reaction Time/drug effects | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Dopaminergic influences on the P300 abnormality in Parkinson's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Gyung W Kim | - |
dc.contributor.googleauthor | Kyoon Huh | - |
dc.contributor.googleauthor | Jin-Soo Kim | - |
dc.identifier.doi | 10.1016/S0022-510X(98)00102-6 | - |
dc.contributor.localId | A00310 | - |
dc.contributor.localId | A01982 | - |
dc.relation.journalcode | J01897 | - |
dc.identifier.eissn | 1878-5883 | - |
dc.identifier.pmid | 9667783 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022510X98001026 | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.citation.volume | 158 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 87 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.158(1) : 83-87, 1998 | - |
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