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Expression of hMSH2 and hMLH1 in Colorectal Carcinomas with Microsatellite Instability

Authors
 Hoguen Kim  ;  Zhe Piao  ;  Jae Woo Kim  ;  Jin Sub Choi  ;  Nam Kyu Kim  ;  Jae Myun Lee  ;  Jeon-Han Park 
Citation
 PATHOLOGY RESEARCH AND PRACTICE, Vol.194(1) : 3-9, 1998 
Journal Title
 PATHOLOGY RESEARCH AND PRACTICE 
ISSN
 0344-0338 
Issue Date
1998
MeSH
Adaptor Proteins, Signal Transducing ; Adult ; Aged ; Blotting, Western ; Carrier Proteins ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism* ; Colorectal Neoplasms/pathology ; DNA Repair/genetics* ; DNA, Neoplasm/analysis ; DNA-Binding Proteins* ; Female ; Gene Expression Regulation, Neoplastic/genetics* ; Humans ; Immunohistochemistry ; Male ; Microsatellite Repeats* ; Middle Aged ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism* ; Nuclear Proteins ; Polymerase Chain Reaction ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism*
Abstract
Warty carcinoma of the uterine cervix is a very rare specific variant of invasive squamous cell carcinoma, usually described as a hybrid feature of condyloma with invasive squamous cell carcinoma. Besides having the koilocytes and maturation of squamous epithelium, there is unequivocal stromal invasion. The feathery surface seems to be characteristic of warty carcinoma, differentiating it from condylomata acuminata or verrucous carcinoma. Using in situ polymerase chain reaction (IS-PCR) and in situ hybridization (ISH) as well as an immunohistochemical technique (IHC), we determined the amplification and expression of several human papilloma virus (HPV) types (6, 11, 33, 16 and 18) in nine warty carcinomas of the uterine cervix. We found amplified HPV predominantly in the nuclei of the feathery surface in all cases only when IS-PCR was applied, while it was detected only in five (55.6%) or six cases (66.7%) by conventional IHC or ISH, respectively. We found multiple types in the same lesion in six cases (66.7%) by IS-PCR, in comparison with ISH which detected a lower incidence (22.2%). This finding of coinfection is more consistent with that seen in low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix than in high SIL. It is important to be aware of these distinct lesions in postmenopausal women with their characteristic feathery and thin surface, as well as a hybrid form of exophytic condyloma and stromal invasion, and frequent coinfection of multiple different HPVs as a type of LSILs.
Full Text
http://www.sciencedirect.com/science/article/pii/S0344033898801313
DOI
10.1016/S0344-0338(98)80131-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Jae Woo(김재우) ORCID logo https://orcid.org/0000-0001-5456-9495
Kim, Hogeun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176292
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