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The Role of Ca 2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis

Authors
 Jung Yun Kang  ;  Namju Kang  ;  Yu-Mi Yang  ;  Jeong Hee Hong  ;  Dong Min Shin 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(10) : E3646, 2020-05 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2020-05
Keywords
NFAT ; calcium signaling ; osteoclast ; transient receptor potential channels
Abstract
The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis.
Files in This Item:
T202001690.pdf Download
DOI
10.3390/ijms21103646
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
Yang, Yu Mi(양유미)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176241
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