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Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

Authors
 Wungrak Choi  ;  Hyoung Won Bae  ;  Hyuna Cho  ;  Eun Woo Kim  ;  Chan Yun Kim  ;  Gong Je Seong 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : 7115, 2020-04 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2020-04
Abstract
This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe's line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients' age group-≤40, 41-50, 51-60, 61-70, 71-80, and 81-92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41-50, 51-60, 61-70, 71-80, and 81-92 years, respectively. The TM height tended to decrease with increasing age (P < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence.
Files in This Item:
T202001542.pdf Download
DOI
10.1038/s41598-020-64048-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Choi, Wungrak(최웅락) ORCID logo https://orcid.org/0000-0002-3015-2502
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176170
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