Cited 28 times in
Triglyceride to HDL-cholesterol Ratio and the Incidence Risk of Type 2 Diabetes in Community Dwelling Adults: A Longitudinal 12-year Analysis of the Korean Genome and Epidemiology Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2020-06-17T00:50:04Z | - |
dc.date.available | 2020-06-17T00:50:04Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176148 | - |
dc.description.abstract | Aims: Serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is known to be associated with cardiometabolic diseases. This study is aimed to evaluate the association between the TG/HDL-C ratio and incident type 2 diabetes with a large-sample, community-based Korean cohort over 12 years. Methods: Among 10,038 participants, a total of 8655 participants aged 40 to 69 years without diabetes were selected from the Korean Genome and Epidemiology Study (KoGES). The baseline TG/HDL-C ratio was divided into quartiles. Newly developed type 2 diabetes was defined by any of the following: a fasting plasma glucose level ≥ 126 mg/dL; a glucose level ≥ 200 mg/dL 2-hours after a 75 g oral glucose tolerance test; an HbA1c ≥ 6.5%; or treatment with anti-diabetic therapy. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes were calculated using multivariate Cox proportional hazards regression models after adjusting for potentially confounding variables. Results: During the 12-year follow-up period, type 2 diabetes developed in 1437 subjects (16.6%, 1437/8655), with incidence rate of 2.8-5.0 (over 2 years). Compared to the reference first quartile, the HRs (95% CIs) of incident type 2 diabetes in the second, third, and fourth quartiles increased in a dose-response manner after adjusting for potentially confounding variables. Conclusions: High TG/HDL-C ratio at baseline may be a useful surrogate indicator of future incident type 2 diabetes. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Triglyceride to HDL-cholesterol Ratio and the Incidence Risk of Type 2 Diabetes in Community Dwelling Adults: A Longitudinal 12-year Analysis of the Korean Genome and Epidemiology Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Tae-Kyeong Lim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1016/j.diabres.2020.108150 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 32305400 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0168822720304009 | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | TG/HDL-C ratio | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 163 | - |
dc.citation.startPage | e108150 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.163 : e108150, 2020-05 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.