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Collateral Augmentation Treatment With a Combination of Acetazolamide and Head-Down Tilt in a Rat Ischemic Stroke Model

Authors
 Minho Han  ;  Il Kwon  ;  Jimin Ha  ;  Jayoung Kim  ;  Myoung-Jin Cha  ;  Young Dae Kim  ;  Ji Hoe Heo  ;  Hyo Suk Nam 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.73 : 252-258, 2020-03 
Journal Title
 JOURNAL OF CLINICAL NEUROSCIENCE 
ISSN
 0967-5868 
Issue Date
2020-03
Keywords
Acetazolamide ; Acute ischemic stroke ; Collateral augmentation treatment ; Head-down tilt ; Middle cerebral artery occlusion ; Outcome
Abstract
Cerebral collaterals is crucially important in the pathophysiology of acute ischemic stroke and associated with outcome after reperfusion therapy. We explored the effectiveness of collateral augmentation treatment with a combination of acetazolamide (ACZ) and head-down tilt (HDT) in the transient middle cerebral artery occlusion (MCAO) rat model. Transient MCAO was induced in all animals for 1.5 h, followed by reperfusion for 22.5 h. Seventy-two male Wistar rats were divided into four treatment groups: control, ACZ, HDT, and combination. Twenty sham rats, which underwent surgery, were randomly allocated to these groups. Twenty-four hours after MCAO or sham surgery, we measured the infarction volume, brain edema (aquaporin-4 [AQP4], and brain water content), and neurological deficits (Garcia and Longa tests). Collateral augmentation treatments were associated with reduced infarction volume, less brain edema, and better neurological outcomes compared with untreated animals. More specifically, ACZ and HDT treatments resulted in small infarction volumes, and HDT was associated with a low AQP4 expression and improved neurological score, while the combination of ACZ and HDT improved neurological scores and reduced brain water content. This study shows that collateral augmentation treatments are associated with a better stroke prognosis compared with untreated animals after transient MCAO. The combination of ACZ and HDT seems to have some synergistic effect, but was not proven to be superior to HDT treatment alone.
Full Text
https://www.sciencedirect.com/science/article/pii/S0967586819322866
DOI
10.1016/j.jocn.2020.01.079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176125
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