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Collateral Augmentation Treatment With a Combination of Acetazolamide and Head-Down Tilt in a Rat Ischemic Stroke Model

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dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author허지회-
dc.date.accessioned2020-06-17T00:47:43Z-
dc.date.available2020-06-17T00:47:43Z-
dc.date.issued2020-03-
dc.identifier.issn0967-5868-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176125-
dc.description.abstractCerebral collaterals is crucially important in the pathophysiology of acute ischemic stroke and associated with outcome after reperfusion therapy. We explored the effectiveness of collateral augmentation treatment with a combination of acetazolamide (ACZ) and head-down tilt (HDT) in the transient middle cerebral artery occlusion (MCAO) rat model. Transient MCAO was induced in all animals for 1.5 h, followed by reperfusion for 22.5 h. Seventy-two male Wistar rats were divided into four treatment groups: control, ACZ, HDT, and combination. Twenty sham rats, which underwent surgery, were randomly allocated to these groups. Twenty-four hours after MCAO or sham surgery, we measured the infarction volume, brain edema (aquaporin-4 [AQP4], and brain water content), and neurological deficits (Garcia and Longa tests). Collateral augmentation treatments were associated with reduced infarction volume, less brain edema, and better neurological outcomes compared with untreated animals. More specifically, ACZ and HDT treatments resulted in small infarction volumes, and HDT was associated with a low AQP4 expression and improved neurological score, while the combination of ACZ and HDT improved neurological scores and reduced brain water content. This study shows that collateral augmentation treatments are associated with a better stroke prognosis compared with untreated animals after transient MCAO. The combination of ACZ and HDT seems to have some synergistic effect, but was not proven to be superior to HDT treatment alone.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherChurchill Livingstone-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCollateral Augmentation Treatment With a Combination of Acetazolamide and Head-Down Tilt in a Rat Ischemic Stroke Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinho Han-
dc.contributor.googleauthorIl Kwon-
dc.contributor.googleauthorJimin Ha-
dc.contributor.googleauthorJayoung Kim-
dc.contributor.googleauthorMyoung-Jin Cha-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.1016/j.jocn.2020.01.079-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ01328-
dc.identifier.eissn1532-2653-
dc.identifier.pmid32037062-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0967586819322866-
dc.subject.keywordAcetazolamide-
dc.subject.keywordAcute ischemic stroke-
dc.subject.keywordCollateral augmentation treatment-
dc.subject.keywordHead-down tilt-
dc.subject.keywordMiddle cerebral artery occlusion-
dc.subject.keywordOutcome-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume73-
dc.citation.startPage252-
dc.citation.endPage258-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROSCIENCE, Vol.73 : 252-258, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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