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Association Between Platelet Count and Osteoarthritis in Women Older Than 50 Years

Authors
 Yu-Jin Kwon  ;  Il-Hyun Koh  ;  Kwangho Chung  ;  Yong-Jae Lee  ;  Hyoung-Sik Kim 
Citation
 THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, Vol.12 : 1759720X20912861, 2020-04 
Journal Title
 THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE 
ISSN
 1759-720X 
Issue Date
2020-04
Keywords
KNHANES ; hip osteoarthritis ; knee osteoarthritis ; platelet count ; women
Abstract
Background: Osteoarthritis (OA) is a multifactorial disease involving inflammatory processes. Platelets play important roles in both hemostasis and the inflammatory response; however, the relationship between platelet count and OA is unclear. Our aim was to evaluate the association between platelet count and knee and hip OA in Korean women. Methods: In this cross-sectional designed study, we included a total of 6011 women aged ⩾50 years from the 2010-2013 Korea National Health and Nutrition Examination Survey. Knee and hip OA were defined as Kellgren-Lawrence grade ⩾2 and presence of knee or hip pain, respectively. Platelet counts were divided into quartiles as follows: Q1, 150-212 (103/µl); Q2, 213-246 (103/µl); Q3, 247-283 (103/µl); and Q4, 284-450 (103/µl). Multiple logistic-regression analysis was conducted to calculate odds ratios and 95% confidence intervals. Receiver operating characteristic analysis was performed to determine the optimal platelet count cut-off with which to discriminate participants with knee and/hip OA versus those without OA. Results: Of the 6011 participants, 1141 (18.1%) had knee or hip OA. The mean age of participants without OA was 60.6 years, and that of participants with OA was 68.0 years. Compared with the lowest quartile, odds ratios (95% confidence intervals) for OA were 1.08 (0.84-1.39) for Q2, 0.94 (0.73-1.23) for Q3, and 1.35 (1.08-1.69) for Q4 after adjusting for confounders. The prevalence of OA was significantly higher with platelet counts ⩾288 × 103/µl, compared with platelet counts <288 × 103/µl. Conclusion: High platelet counts within the normal range are significantly associated with knee and hip OA.
Files in This Item:
T202001237.pdf Download
DOI
10.1177/1759720X20912861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Il Hyun(고일현) ORCID logo https://orcid.org/0000-0001-9823-8516
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Kim, Hyoung Sik(김형식) ORCID logo https://orcid.org/0000-0002-9303-4116
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Chung, Kwangho(정광호) ORCID logo https://orcid.org/0000-0003-3097-3332
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176064
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