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Differential Diabetogenic Effect of Pitavastatin and Rosuvastatin, in Vitro and in Vivo

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author왕혜진-
dc.contributor.author이향규-
dc.contributor.author조용인-
dc.contributor.author최은영-
dc.date.accessioned2020-06-17T00:29:55Z-
dc.date.available2020-06-17T00:29:55Z-
dc.date.issued2020-05-
dc.identifier.issn1340-3478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175995-
dc.description.abstractAim: Most statins increase the risk of new-onset diabetes. Unlike other statins, pitavastatin is reported to exert neutral effects on serum glucose level, but the precise mechanism is unknown. Methods: Eight-week-old male C57BL/6J mice (n=26) were fed high-fat diet (HFD, 45% fat) with 0.01% placebo, rosuvastatin, or pitavastatin for 12 weeks. Cultured HepG2, C2C12, and 3T3-L1 cells and visceral adipocytes from HFD-fed mice were treated with vehicle or 10 µM statins for 24 h. The effects of pitavastatin and rosuvastatin on intracellular insulin signaling and glucose transporter 4 (GLUT4) translocation were evaluated. Results: After 12 weeks, the fasting blood glucose level was significantly lower in pitavastatin-treated group than in rosuvastatin-treated group (115.2±7.0 versus 137.4±22.3 mg/dL, p=0.024). Insulin tolerance significantly improved in pitavastatin-treated group as compared with rosuvastatin-treated group, and no significant difference was observed in glucose tolerance. Although plasma adiponectin and insulin levels were not different between the two statin treatment groups, the insulin-induced protein kinase B phosphorylation was weakly attenuated in pitavastatin-treated adipocytes than in rosuvastatin-treated adipocytes. Furthermore, minor attenuation in insulin-induced GLUT4 translocation to the plasma membrane of adipocytes was observed in pitavastatin-treated group. Conclusion: Pitavastatin showed lower diabetogenic effects than rosuvastatin in mice that may be mediated by minor attenuations in insulin signaling in adipocytes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJapan Atherosclerosis Society-
dc.relation.isPartOfJOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDifferential Diabetogenic Effect of Pitavastatin and Rosuvastatin, in Vitro and in Vivo-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYongin Cho-
dc.contributor.googleauthorHyangkyu Lee-
dc.contributor.googleauthorHyun Ki Park-
dc.contributor.googleauthorEun Yeong Choe-
dc.contributor.googleauthorHye Jin Wang-
dc.contributor.googleauthorRyeong-Hyeon Kim-
dc.contributor.googleauthorYoujin Kim-
dc.contributor.googleauthorEun Seok Kang-
dc.identifier.doi10.5551/jat.50039-
dc.contributor.localIdA00068-
dc.contributor.localIdA02422-
dc.contributor.localIdA02422-
dc.contributor.localIdA03282-
dc.contributor.localIdA03282-
dc.contributor.localIdA03866-
dc.contributor.localIdA03866-
dc.contributor.localIdA04153-
dc.contributor.localIdA04153-
dc.relation.journalcodeJ01252-
dc.identifier.eissn1880-3873-
dc.identifier.pmid31527323-
dc.subject.keywordAdipocyte-
dc.subject.keywordDiabetes-
dc.subject.keywordInsulin resistance-
dc.subject.keywordInsulin signaling-
dc.subject.keywordPitavastatin-
dc.subject.keywordRosuvastatin-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.affiliatedAuthor강은석-
dc.contributor.affiliatedAuthor왕혜진-
dc.contributor.affiliatedAuthor왕혜진-
dc.contributor.affiliatedAuthor이향규-
dc.contributor.affiliatedAuthor이향규-
dc.contributor.affiliatedAuthor조용인-
dc.contributor.affiliatedAuthor조용인-
dc.contributor.affiliatedAuthor최은영-
dc.contributor.affiliatedAuthor최은영-
dc.citation.volume27-
dc.citation.number5-
dc.citation.startPage429-
dc.citation.endPage440-
dc.identifier.bibliographicCitationJOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.27(5) : 429-440, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers

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