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Alterations in Glucose Metabolism in Vibrio Cholerae Serogroup O1 El Tor Biotype Strains

Authors
 Donghyun Lee  ;  Eun Jin Kim  ;  Yeongjun Baek  ;  Jiwon Lee  ;  Youngbae Yoon  ;  G B Nair  ;  Sang Sun Yoon  ;  Dong Wook Kim 
Citation
 SCIENTIFIC REPORTS, Vol.10(1) : e308, 2020-01 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2020-01
Abstract
The 2 biotypes of Vibrio cholerae O1 serogroup strains-classical and El Tor-use glucose in distinct ways. Classical biotype strains perform organic acid-producing fermentation and eventually lose viability due to the self-induced creation of an acidic environment, whereas El Tor biotype strains use an alternative neutral fermentation pathway, which confers them with survival advantages. However, we report that the neutral fermentation pathway has only been recruited in prototype Wave 1 El Tor biotype strains, which have not been isolated since the mid-1990s. Current Wave 2 and Wave 3 atypical El Tor strains contain a single-base deletion in a gene that directs bacteria toward neutral fermentation, resulting in the loss of neutral fermentation and an appearance that is similar to classical biotype strains. Moreover, when sufficient glucose was supplied, Wave 1 El Tor strains maintained their use of acid-producing fermentation, in parallel with neutral fermentation, and thus lost viability in the late stationary phase. The global replacement of Wave 1 El Tor strains by Wave 2 and 3 atypical El Tor strains implies that the acidic fermentation pathway may not be disadvantageous to V. cholerae. The characteristics that we have reported might improve oral rehydration in the treatment of cholera.
Files in This Item:
T202000956.pdf Download
DOI
10.1038/s41598-019-57093-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175961
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