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Use of RBC Deformability Index as an Early Marker of Diabetic Nephropathy

Authors
 Sang Bae Lee  ;  Yu-Sik Kim  ;  Jung Hye Kim  ;  Kahui Park  ;  Ji Sun Nam  ;  Shinae Kang  ;  Jong Suk Park  ;  Sehyun Shin  ;  Chul Woo Ahn 
Citation
 CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, Vol.72(1) : 75-84, 2019-07 
Journal Title
 CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 
ISSN
 1386-0291 
Issue Date
2019-07
MeSH
Cross-Sectional Studies ; Diabetes Mellitus, Type 2 / complications* ; Diabetes Mellitus, Type 2 / physiopathology ; Diabetic Nephropathies / diagnosis* ; Diabetic Nephropathies / pathology ; Erythrocyte Deformability / physiology* ; Female ; Hemorheology* ; Humans ; Male ; Middle Aged
Keywords
Diabetic nephropathy ; RBC deformability ; elongation index ; hemorheology
Abstract
Background and objective: Hemorheologic alterations have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters and assessed their possible role as a diagnostic tool for diabetic nephropathy (DN). Methods: 248 subjects with type 2 diabetes and 222 subjects with prediabetes were included in this study. Hemorheologic parameters, including erythrocyte sedimentation rate (ESR), elongation index at 3 Pa (EI) were measured using microfluidic hemorheometer. Various metabolic parameters were measured from fasting blood samples. The subjects were stratified into three groups according to classification of DN by urinary albumin to creatinine ratio (ACR) and four groups by estimated glomerular filtration rate (GFR), than analyzed. Results: Significant differences were observed in metabolic and hemorheologic parameters according to progression of DN. Among them, (Fibrinogen×ESR)/ EI differed in all three groups of urinary ACR. In multiple regression analysis, (Fibrinogen×ESR)/ EI was an independent predictor of urine ACR after adjusted with confounding factors (ß = 0.010, p < 0.001). (Fibrinogen×ESR)/ EI also showed significant difference no or minimal CKD stage, moderate CKD and severe CKD classified by GFR. This parameter showed area under curve (AUC) of the receiver operating characteristic (ROC) curve of 0.762, and moderate sensitivity and specificity to predict prevalence of microalbuminuria. Conclusions: (Fibrinogen×ESR)/ EI is a sensitive parameter for screening diabetic nephropathy.
Full Text
https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch180434
DOI
10.3233/CH-180434
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Vascular and Metabolic Research (혈관대사연구소) > 1. Journal Papers
Yonsei Authors
Kang, Shin Ae(강신애) ORCID logo https://orcid.org/0000-0002-9719-4774
Kim, Yu-Sik(김유식)
Kim, Jung Hye(김정혜)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Kahui(박가희)
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Sang Bae(이상배) ORCID logo https://orcid.org/0000-0002-2998-6534
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175818
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