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Clinical Evaluation of a Novel Micro-lancet (ML) for Minimizing Lancing Pain

Authors
 Yonghao Ma  ;  Chisong Lee  ;  Ghunil Lee  ;  Yonggeun Cho  ;  Sang-Guk Lee  ;  Hyungil Jung 
Citation
 BIOCHIP JOURNAL, Vol.13(4) : 394-402, 2019-12 
Journal Title
 BIOCHIP JOURNAL 
ISSN
 1976-0280 
Issue Date
2019-12
Abstract
Patients with diabetes are required to lance their fingers daily for self-monitoring their blood glucose level. Patients might be reluctant to use commercial lancets with thick outer diameters due to lancing pain; this results in the worsening of their health. A metallic microneedle is an ideal substitute to the commercial lancet system and offers a minimally invasive and patient friendly approach for capillary blood extraction. However, reports regarding the performance of sufficient long and high stiffness microneedles for innocuous and efficient capillary blood sampling for conducting clinical trials are rare. Here, we developed a novel micro-lancet (ML) that is 3 mm long and has a 130 µm outer diameter and a sharp beveled 15° tip. ML induced lesser tissue damage than the commercial ACCU-CHEK Softclix in a porcine skin test. Through a clinical study, we demonstrated that the pain scores using the commercial lancet and ML were 3.4 and 0.8 the numeric pain rating scale, respectively. The average blood volume drawn using the ML was 0.96 µL, which satisfies the minimum requirement (0.3 µL) for glucose detection. This novel ML may improve patient compliance to blood glucose monitoring procedures by reducing lancing-related pain.
Full Text
https://link.springer.com/article/10.1007/s13206-019-3411-4
DOI
10.1007/s13206-019-3411-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175811
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