Cited 61 times in
Magnetic Resonance Imaging-Visible Perivascular Spaces in Basal Ganglia Predict Cognitive Decline in Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | 박예원 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 이승구 | - |
dc.date.accessioned | 2020-04-17T01:19:39Z | - |
dc.date.available | 2020-04-17T01:19:39Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0885-3185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175698 | - |
dc.description.abstract | BACKGROUND: Growing evidence suggests an association between imaging biomarkers of small vessel disease and future cognitive decline in Parkinson's disease (PD). Recently, magnetic resonance imaging-visible perivascular space (PVS) has been considered as an imaging biomarker of small vessel disease, but its effect on cognitive decline in PD is yet to be investigated. OBJECTIVE: The objective of this study was to evaluate whether PVS can independently predict cognitive decline in PD. METHODS: A total of 271 PD patients were divided into 106 patients with intact cognition (PD-IC) and 165 patients with mild cognitive impairment (PD-MCI). After a mean follow-up of 5.0 ± 2.3 years, 18 PD-IC patients showed cognitive decline to PD-MCI and 34 PD-MCI patients showed cognitive decline to dementia. PVS was rated in the basal ganglia (BG) and centrum semiovale using a 4-point visual scale and then classified as high (score ≥ 2) or low (score < 2) according to severity. Lacunes and white matter hyperintensity severity were also assessed. Independent risk factors for cognitive decline were investigated using multivariable logistic regression analysis. RESULTS: In all patients, higher BG-PVS and white matter hyperintensity severity, higher levodopa-equivalent dose, hypertension, and lower Mini-Mental State Examination score were independent positive predictors of future cognitive decline. In the PD-IC subgroup, higher BG-PVS severity, hypertension, and more severe depressive symptoms were predictors of cognitive conversion. In the PD-MCI subgroup, higher BG-PVS and white matter hyperintensity severity, and lower Mini-Mental State Examination score were predictors of cognitive decline. CONCLUSIONS: BG-PVS may be a useful imaging marker for predicting cognitive decline in PD. © 2019 International Parkinson and Movement Disorder Society. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | MOVEMENT DISORDERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Magnetic Resonance Imaging-Visible Perivascular Spaces in Basal Ganglia Predict Cognitive Decline in Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Yae Won Park | - |
dc.contributor.googleauthor | Na‐Young Shin | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Jiwoong Kim | - |
dc.contributor.googleauthor | Soo Mee Lim | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Seung‐Koo Lee | - |
dc.contributor.googleauthor | Kook Jin Ahn | - |
dc.identifier.doi | 10.1002/mds.27798 | - |
dc.contributor.localId | A05330 | - |
dc.contributor.localId | A04666 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A02912 | - |
dc.relation.journalcode | J02275 | - |
dc.identifier.eissn | 1531-8257 | - |
dc.identifier.pmid | 31322758 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/mds.27798 | - |
dc.subject.keyword | Lacune | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | cognition | - |
dc.subject.keyword | perivascular space | - |
dc.subject.keyword | white matter hyperintensity | - |
dc.contributor.alternativeName | Park, Yae-Won | - |
dc.contributor.affiliatedAuthor | 박예원 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1672 | - |
dc.citation.endPage | 1679 | - |
dc.identifier.bibliographicCitation | MOVEMENT DISORDERS, Vol.34(11) : 1672-1679, 2019 | - |
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