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시상하부 과오종에 대한 감마나이프방사선수술의 장기추적 결과:치료성적을 어떻게 높일 수 있을까?

Other Titles
 Long-Term Follow-Up Results of Gamma Knife Radiosurgery for Hypothalamic Hamartoma : How can we Improve the Results? 
 권영섭  ;  박용숙  ;  정현호  ;  장종희  ;  김동석  ;  장진우  ;  이병인  ;  박용구  ;  최중언  ;  정상섭 
 Journal of the Korean Society of Stereotactic and Functional Neurosurgery (대한정위기능신경외과학회지), Vol.1(2) : 183-190, 2005 
Journal Title
Journal of the Korean Society of Stereotactic and Functional Neurosurgery(대한정위기능신경외과학회지)
Issue Date
Epilepsy ; Gamma Knife radiosurgery ; Gelastic seizure ; Hypothalamic hamartoma ; Precocious puberty.
Objective: Hypothalamic hamartomas (HH) constitute rare developmental lesions associated with gelastic seizure, precocious puberty, and abnormal behavior. Treatment for this lesion is very complicated due to its location. Gamma Knife radiosurgery (GKS) may be an efficient and safe treatment option, which produces little morbidity. The authors evaluated the long-term results of GKS for the HH. Methods: Eights patients with HH-related intractable gelastic seizure and/or precocious puberty underwent GKS between 1992 and 1996, with a mean age of 8.3 years at the time of GKS (range, 3.5-17.7 years). Three patients were presented with intractable gelastic seizure, and 4 patients with precocious puberty. One patient had both intractable seizure and precocious puberty. The mean follow-up duration was 76.6 (28.9-141) months. Results: The mean marginal dose for the large sessile type HH with intractable gelastic seizure was 11.5Gy (range, 9-13Gy) and that for the small pedunculated type with precocious puberty was 27Gy (range, 20-34Gy). There was no lesion volume change on follow-up MRI. Intractable seizure disappeared in only 1 patient and was not improved in the other 3 patients. Precocious puberty was not resolved by GKS in all cases. Conclusion: The long-term results of GKS for HH were not satisfactory. As for the control of epilepsy, the radiation dose in our cases was not enough to suppress and block the epileptogenic focus of HH and its propagation to surrounding tissue. Precocious puberty caused by HH is not indicated for GKS. If we could get better treatment outcome with higher radiation dose and/ or new dose planning technique, GKS might be primary treatment option for HH.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Park, Yong Gou(박용구)
Lee, Byung In(이병인)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
Choi, Joong Uhn(최중언)
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