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Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging study (STAMINA-MRI Study)

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dc.contributor.author차지훈-
dc.date.accessioned2020-04-13T17:00:30Z-
dc.date.available2020-04-13T17:00:30Z-
dc.date.issued2020-
dc.identifier.issn0022-3050-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175612-
dc.description.abstractOBJECTIVE: Intracranial atherosclerosis is a major cause of ischaemic stroke worldwide. A number of studies have shown the effects of statin treatment on coronary and carotid artery plaques, but there is little evidence on the effects of statin treatment on intracranial atherosclerotic plaques. METHODS: The Intensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging (STAMINA-MRI) Trial is a single-arm, prospective, observational study monitoring imaging and clinical outcomes of high-dose statin treatment among statin-naive patients with acute ischaemic stroke caused by symptomatic intracranial atherosclerosis. The primary outcome was the change in vascular remodelling and plaque characteristics before and after 6 months (median: 179 days, IQR 163-189 days) of statin treatment measured by high-resolution MRI (HR-MRI). RESULTS: A total of 77 patients (mean age: 62.6±13.7 years, 61.0% women) were included in this study. Low-density lipoprotein cholesterol (LDL-C) levels (mg/dL) at initial and follow-up assessments were 125.81±35.69 and 60.95±19.28, respectively. Overall, statin treatment significantly decreased enhancement of plaque volume (mm3, 32.07±39.15 vs 17.06±34.53, p=0.013), the wall area index (7.50±4.28 vs 5.86±4.05, p=0.016) and stenosis degree (%, 76.47±20.23 vs 64.05±21.29, p<0.001), but not the remodelling index (p=0.195). However, 35% patients showed no change or increased enhancement volume and stenosis degree after statin treatment. Higher reduction of LDL-C and longer duration of statin treatment were associated with decreased enhancement volume after statin treatment. CONCLUSIONS: High-dose statin treatment effectively stabilised symptomatic intracranial atherosclerotic plaques as documented by HR-MRI. Further study is needed to determine laboratory and genetic factors associated with poor response to statins and alternative therapeutic options, such as proprotein convertase subtilisin-kexin type 9 inhibitors, for these patients. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT02458755.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBMJ Publishing Group-
dc.relation.isPartOfJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntensive Statin Treatment in Acute Ischaemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging study (STAMINA-MRI Study)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorJong-Won Chung-
dc.contributor.googleauthorJihoon Cha-
dc.contributor.googleauthorMi Ji Lee-
dc.contributor.googleauthorIn-Wu Yu-
dc.contributor.googleauthorMoo-Seok Park-
dc.contributor.googleauthorWoo-Keun Seo-
dc.contributor.googleauthorSung Tae Kim-
dc.contributor.googleauthorOh Young Bang-
dc.identifier.doi10.1136/jnnp-2019-320893-
dc.contributor.localIdA05808-
dc.relation.journalcodeJ01628-
dc.identifier.eissn1468-330X-
dc.identifier.pmid31371644-
dc.identifier.urlhttps://jnnp.bmj.com/content/91/2/204.long-
dc.subject.keywordcerebral infarction-
dc.subject.keywordhigh-resolution MRI-
dc.subject.keywordintracranial atherosclerosis-
dc.subject.keywordstatins-
dc.subject.keywordstroke-
dc.contributor.alternativeNameCha, Jihoon-
dc.contributor.affiliatedAuthor차지훈-
dc.citation.volume91-
dc.citation.number2-
dc.citation.startPage204-
dc.citation.endPage211-
dc.identifier.bibliographicCitationJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.91(2) : 204-211, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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