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Utility of FDG PET/CT for Preoperative Staging of Non-Small Cell Lung Cancers Manifesting as Subsolid Nodules With a Solid Portion of 3 cm or Smaller

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dc.contributor.author서영주-
dc.date.accessioned2020-04-13T17:00:23Z-
dc.date.available2020-04-13T17:00:23Z-
dc.date.issued2020-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175610-
dc.description.abstractOBJECTIVE. The objective of our study was to investigate the utility of FDG PET/CT for the preoperative staging of subsolid non-small cell lung cancers (NSCLCs) with a solid portion size of 3 cm or smaller. MATERIALS AND METHODS. We retrospectively enrolled 855 patients with pathologically proven NSCLCs manifesting as subsolid nodules with a solid portion of 3 cm or smaller on CT. We then compared the diagnostic performances of FDG PET/CT and chest CT for detecting lymph node (LN), intrathoracic, or distant metastases in patients who underwent preoperative chest CT and FDG PET/CT. After propensity score matching, we compared the diagnostic performance of FDG PET/CT in the group who underwent both chest CT and FDG PET/CT with that of chest CT in patients who did not undergo FDG PET/CT. RESULTS. There were LN metastases in 25 of 765 patients (3.3%) who underwent surgical LN dissection or biopsy and intrathoracic or distant metastasis in two of 855 patients (0.2%). For LN staging, FDG PET/CT showed a sensitivity of 44.0%, specificity of 81.5%, positive predictive value of 9.6%, negative predictive value of 97.0%, and accuracy of 79.9%, which were lower than those of chest CT for accuracy (p < 0.0001). FDG PET/CT could not accurately detect any intrathoracic or distant metastasis. After propensity score matching, the diagnostic accuracy for LN staging of FDG PET/CT in the group who underwent both CT and FDG PET/CT was lower than that of chest CT in the group who did not undergo FDG PET/CT (p = 0.002), and the diagnostic accuracy for intrathoracic and distant metastases was not different (p > 0.999). CONCLUSION. FDG PET/CT has limited utility in preoperatively detecting LN or distant metastasis in patients with subsolid NSCLCs with a solid portion size of 3 cm or smaller.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringfield, Ill., Thomas-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleUtility of FDG PET/CT for Preoperative Staging of Non-Small Cell Lung Cancers Manifesting as Subsolid Nodules With a Solid Portion of 3 cm or Smaller-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorYoung Joo Suh-
dc.contributor.googleauthorChang Min Park-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorSun Kyung Jeon-
dc.contributor.googleauthorHyungjin Kim-
dc.contributor.googleauthorEui Jin Hwang-
dc.contributor.googleauthorJong Hyuk Lee-
dc.contributor.googleauthorJin Chul Paeng-
dc.contributor.googleauthorChang Hoon Lee-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorJin Mo Goo-
dc.identifier.doi10.2214/AJR.19.21811-
dc.contributor.localIdA01892-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid31846374-
dc.identifier.urlhttps://www.ajronline.org/doi/full/10.2214/AJR.19.21811-
dc.subject.keywordCT-
dc.subject.keywordPET-
dc.subject.keywordcancer staging-
dc.subject.keywordnon–small cell lung cancer-
dc.subject.keywordsubsolid nodule-
dc.contributor.alternativeNameSuh, Young Joo-
dc.contributor.affiliatedAuthor서영주-
dc.citation.volume214-
dc.citation.number3-
dc.citation.startPage514-
dc.citation.endPage523-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.214(3) : 514-523, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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