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Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

Authors
 Jihyeon Lee  ;  Won Seok Chang  ;  Jaewoo Shin  ;  Younghee Seo  ;  Chanho Kong  ;  Byeong-Wook Song  ;  Young Cheol Na  ;  Bong Soo Kim  ;  Jin Woo Chang 
Citation
 STEM CELL RESEARCH, Vol.43 : e101726, 2020 
Journal Title
STEM CELL RESEARCH
ISSN
 1873-5061 
Issue Date
2020
Keywords
Cell adhesion molecules ; Cell migration ; Cytokines ; Mesenchymal stem cells ; Stem cell transplantation ; Stem cell-microenvironment interactions
Abstract
Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.
Files in This Item:
T202000814.pdf Download
DOI
10.1016/j.scr.2020.101726
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Bong Soo(김봉수)
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175606
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