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Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules

DC Field Value Language
dc.contributor.author김봉수-
dc.contributor.author장원석-
dc.contributor.author장진우-
dc.contributor.author장원석-
dc.contributor.author장진우-
dc.date.accessioned2020-04-13T17:00:02Z-
dc.date.available2020-04-13T17:00:02Z-
dc.date.issued2020-
dc.identifier.issn1873-5061-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175606-
dc.description.abstractAlthough there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality for the treatment of brain diseases, including neurodegenerative disorders. The various biological effects of FUS treatment have been investigated; therefore, the goal is now to improve the delivery efficiency and function of MSCs by capitalizing on the advantages of FUS. In this study, we demonstrated that FUS increases MSC transplantation into brain tissue by >2-fold, and that this finding might be related to the activation of intercellular adhesion molecule-1 in endothelial and subendothelial cells and vascular adhesion molecule-1 in endothelial cells.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfSTEM CELL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleNon-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJihyeon Lee-
dc.contributor.googleauthorWon Seok Chang-
dc.contributor.googleauthorJaewoo Shin-
dc.contributor.googleauthorYounghee Seo-
dc.contributor.googleauthorChanho Kong-
dc.contributor.googleauthorByeong-Wook Song-
dc.contributor.googleauthorYoung Cheol Na-
dc.contributor.googleauthorBong Soo Kim-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1016/j.scr.2020.101726-
dc.contributor.localIdA00515-
dc.contributor.localIdA03454-
dc.contributor.localIdA03454-
dc.contributor.localIdA03484-
dc.contributor.localIdA03484-
dc.contributor.localIdA03454-
dc.contributor.localIdA03454-
dc.contributor.localIdA03484-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ02680-
dc.identifier.eissn1876-7753-
dc.identifier.pmid32028085-
dc.subject.keywordCell adhesion molecules-
dc.subject.keywordCell migration-
dc.subject.keywordCytokines-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordStem cell transplantation-
dc.subject.keywordStem cell-microenvironment interactions-
dc.contributor.alternativeNameKim, Bong Soo-
dc.contributor.affiliatedAuthor김봉수-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장원석-
dc.contributor.affiliatedAuthor장진우-
dc.contributor.affiliatedAuthor장진우-
dc.citation.volume43-
dc.citation.startPagee101726-
dc.identifier.bibliographicCitationSTEM CELL RESEARCH, Vol.43 : e101726, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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