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Hydrogel cross-linking-programmed release of nitric oxide regulates source-dependent angiogenic behaviors of human mesenchymal stem cell

DC Field Value Language
dc.contributor.author강미란-
dc.contributor.author권병주-
dc.contributor.author백우열-
dc.contributor.author성학준-
dc.contributor.author이용재-
dc.contributor.author최영식-
dc.date.accessioned2020-04-13T16:59:34Z-
dc.date.available2020-04-13T16:59:34Z-
dc.date.issued2020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175603-
dc.description.abstractAngiogenesis is stimulated by nitric oxide (NO) production in endothelial cells (ECs). Although proangiogenic actions of human mesenchymal stem cells (hMSCs) have been extensively studied, the mechanistic role of NO in this action remains obscure. Here, we used a gelatin hydrogel that releases NO upon crosslinking by a transglutaminase reaction ("NO gel"). Then, the source-specific behaviors of bone marrow versus adipose tissue-derived hMSCs (BMSCs versus ADSCs) were monitored in the NO gels. NO inhibition resulted in significant decreases in their angiogenic activities. The NO gel induced pericyte-like characteristics in BMSCs in contrast to EC differentiation in ADSCs, as evidenced by tube stabilization versus tube formation, 3D colocalization versus 2D coformation with EC tube networks, pericyte-like wound healing versus EC-like vasculogenesis in gel plugs, and pericyte versus EC marker production. These results provide previously unidentified insights into the effects of NO in regulating hMSC source-specific angiogenic mechanisms and their therapeutic applications. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHydrogel cross-linking-programmed release of nitric oxide regulates source-dependent angiogenic behaviors of human mesenchymal stem cell-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorMi-Lan Kang-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorJin You-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorByeong-Ju Kwon-
dc.contributor.googleauthorChan Hee Park-
dc.contributor.googleauthorWooyeol Baek-
dc.contributor.googleauthorMin Sup Kim-
dc.contributor.googleauthorYong Jae Lee-
dc.contributor.googleauthorGun-Il Im-
dc.contributor.googleauthorJeong-Kee Yoon-
dc.contributor.googleauthorJung Bok Lee-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1126/sciadv.aay5413-
dc.contributor.localIdA05812-
dc.contributor.localIdA00218-
dc.contributor.localIdA04949-
dc.contributor.localIdA01958-
dc.contributor.localIdA05165-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ03735-
dc.identifier.eissn2375-2548-
dc.identifier.pmid32133403-
dc.contributor.alternativeNameKang, Mi-Lan-
dc.contributor.affiliatedAuthor강미란-
dc.contributor.affiliatedAuthor권병주-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor이용재-
dc.contributor.affiliatedAuthor최영식-
dc.citation.volume6-
dc.citation.number9-
dc.citation.startPageeaay5413-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, Vol.6(9) : eaay5413, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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