Cited 11 times in
Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model
DC Field | Value | Language |
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dc.contributor.author | 김명준 | - |
dc.contributor.author | 신재승 | - |
dc.contributor.author | 신현주 | - |
dc.contributor.author | 윤혜성 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2020-04-13T16:54:16Z | - |
dc.date.available | 2020-04-13T16:54:16Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175559 | - |
dc.description.abstract | BACKGROUND: Hepatic sinusoidal obstruction syndrome (SOS) is caused by damage to hepatic sinusoidal endothelial cells that results in fibrous obliteration of intrahepatic venules and necrosis of hepatocytes. Currently the diagnosis is primarily based on nonspecific clinical features and invasive liver biopsy. Therefore, noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic SOS. AIM: To determine the effectiveness of supersonic shear wave imaging (SSI) and dual energy computed tomography (DECT) for diagnosing hepatic SOS using a rabbit model. METHODS: Among nine New Zealand white rabbits (3-4 kg, male), three in control group ingested normal saline for 20 d and six in the SOS group ingested 6-thioguanine (5 mg/kg/d) for 20 d. Liver stiffness was measured using SSI on days 0, 3, 10, and 20. On the same days, liver perfusion was evaluated from virtual monochromatic images of 55 keV and iodine map using DECT. Morphologic changes in the liver were assessed using CT. Final pathology scores were compared between the two groups. Liver stiffness and perfusion parameters were compared according to the groups, days, and pathology scores. RESULTS: Final pathology scores were significantly higher in the SOS than the control group (median 22 vs 2, P = 0.024). No gross morphologic changes were seen in livers. Liver stiffness, Hounsfield Unit values, and iodine concentrations were higher in the SOS compared to the control group on days 10 and 20 (all, P ≤ 0.007). Compared to day 0, liver stiffness and perfusion parameters were higher on day 20 in the SOS group (all, P ≤ 0.001). Correlation coefficients for liver stiffness (r = 0.635), Hounsfield Unit values (r = 0.587), and iodine concentration (r = 0.611) with final pathology scores were positive without significance (all, P > 0.05). CONCLUSION: Liver stiffness and perfusion parameters were significantly increased in the livers of a rabbit SOS model. SSI and DECT might aid in early diagnosis of hepatic SOS. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Baishideng Publishing Group | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jaeseung Shin | - |
dc.contributor.googleauthor | Haesung Yoon | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Mi-Jung Lee | - |
dc.contributor.googleauthor | Myung-Joon Kim | - |
dc.contributor.googleauthor | Hyun Joo Shin | - |
dc.identifier.doi | 10.3748/wjg.v26.i7.706 | - |
dc.contributor.localId | A00425 | - |
dc.contributor.localId | A05599 | - |
dc.contributor.localId | A02178 | - |
dc.contributor.localId | A04989 | - |
dc.contributor.localId | A02774 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 32116418 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Computed tomography | - |
dc.subject.keyword | Elasticity imaging techniques | - |
dc.subject.keyword | Hepatic sinusoidal obstruction syndrome | - |
dc.subject.keyword | Iodine | - |
dc.subject.keyword | Liver | - |
dc.contributor.alternativeName | Kim, Myung Joon | - |
dc.contributor.affiliatedAuthor | 김명준 | - |
dc.contributor.affiliatedAuthor | 신재승 | - |
dc.contributor.affiliatedAuthor | 신현주 | - |
dc.contributor.affiliatedAuthor | 윤혜성 | - |
dc.contributor.affiliatedAuthor | 이미정 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 706 | - |
dc.citation.endPage | 716 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.26(7) : 706-716, 2020 | - |
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