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Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research

Authors
 So Yeong Cheon  ;  Jeongmin Kim  ;  So Yeon Kim  ;  Eun Jung Kim  ;  Bon-Nyeo Koo 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(3) : E1103, 2020 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2020
Keywords
IL-18 ; IL-1β ; caspase-1 ; cognitive symptoms ; inflammasome ; inflammatory disease ; neurodegenerative disease
Abstract
Cognitive symptoms are prevalent in the elderly and are associated with an elevated risk of developing dementia. Disease-driven changes can cause cognitive disabilities in memory, attention, and language. The inflammasome is an innate immune intracellular complex that has a critical role in the host defense system, in that it senses infectious pathogen-associated and endogenous danger-associated molecular patterns. An unbalanced or dysregulated inflammasome is associated with infectious, inflammatory, and neurodegenerative diseases. Due to its importance in such pathological conditions, the inflammasome is an emerging drug target for human diseases. A growing number of studies have revealed links between cognitive symptoms and the inflammasome. Several studies have shown that reducing the inflammasome component mitigates cognitive symptoms in diseased states. Therefore, understanding the inflammasome regulatory mechanisms may be required for the prevention and treatment of cognitive symptoms. The purpose of this review is to discuss the current understanding of the inflammasome and its relationships with cognitive symptoms in various human diseases.
Files in This Item:
T202000626.pdf Download
DOI
10.3390/ijms21031103
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koo, Bon-Nyeo(구본녀) ORCID logo https://orcid.org/0000-0002-3189-1673
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Kim, Eun Jung(김은정) ORCID logo https://orcid.org/0000-0002-5693-1336
Kim, Jeongmin(김정민) ORCID logo https://orcid.org/0000-0002-0468-8012
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175541
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