Cited 11 times in
Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김소연 | - |
dc.contributor.author | 김은정 | - |
dc.contributor.author | 김정민 | - |
dc.date.accessioned | 2020-04-13T16:51:37Z | - |
dc.date.available | 2020-04-13T16:51:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175541 | - |
dc.description.abstract | Cognitive symptoms are prevalent in the elderly and are associated with an elevated risk of developing dementia. Disease-driven changes can cause cognitive disabilities in memory, attention, and language. The inflammasome is an innate immune intracellular complex that has a critical role in the host defense system, in that it senses infectious pathogen-associated and endogenous danger-associated molecular patterns. An unbalanced or dysregulated inflammasome is associated with infectious, inflammatory, and neurodegenerative diseases. Due to its importance in such pathological conditions, the inflammasome is an emerging drug target for human diseases. A growing number of studies have revealed links between cognitive symptoms and the inflammasome. Several studies have shown that reducing the inflammasome component mitigates cognitive symptoms in diseased states. Therefore, understanding the inflammasome regulatory mechanisms may be required for the prevention and treatment of cognitive symptoms. The purpose of this review is to discuss the current understanding of the inflammasome and its relationships with cognitive symptoms in various human diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Inflammasome and Cognitive Symptoms in Human Diseases: Biological Evidence from Experimental Research | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | So Yeong Cheon | - |
dc.contributor.googleauthor | Jeongmin Kim | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Eun Jung Kim | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.3390/ijms21031103 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00616 | - |
dc.contributor.localId | A00816 | - |
dc.contributor.localId | A00884 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 32046097 | - |
dc.subject.keyword | IL-18 | - |
dc.subject.keyword | IL-1β | - |
dc.subject.keyword | caspase-1 | - |
dc.subject.keyword | cognitive symptoms | - |
dc.subject.keyword | inflammasome | - |
dc.subject.keyword | inflammatory disease | - |
dc.subject.keyword | neurodegenerative disease | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | 구본녀 | - |
dc.contributor.affiliatedAuthor | 김소연 | - |
dc.contributor.affiliatedAuthor | 김은정 | - |
dc.contributor.affiliatedAuthor | 김정민 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | E1103 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(3) : E1103, 2020 | - |
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