Cited 4 times in
Dynamic hyperpolarized 13 C MR spectroscopic imaging using SPICE in mouse kidney at 9.4 T
DC Field | Value | Language |
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dc.contributor.author | 송호택 | - |
dc.date.accessioned | 2020-04-13T16:50:37Z | - |
dc.date.available | 2020-04-13T16:50:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175533 | - |
dc.description.abstract | This study aims to investigate the feasibility of dynamic hyperpolarized 13 C MR spectroscopic imaging (MRSI) using the SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE) technique and an estimation of the spatially resolved conversion constant rate (kpl ). An acquisition scheme comprising a single training dataset and several imaging datasets was proposed considering hyperpolarized 13 C circumstances. The feasibility and advantage of the scheme were investigated in two parts: (a) consistency of spectral basis over time and (b) accuracy of the estimated kpl . The simulations and in vivo experiments support accurate kpl estimation with consistent spectral bases. The proposed method was implemented in an enzyme phantom and via in vivo experiments. In the enzyme phantom experiments, spatially resolved homogeneous kpl maps were observed. In the in vivo experiments, normal diet (ND) mice and high-fat diet (HFD) mice had kpl (s-1 ) values of medullar (ND: 0.0119 ± 0.0022, HFD: 0.0195 ± 0.0005) and cortical (ND: 0.0148 ±0.0023, HFD: 0.0224 ±0.0054) regions which were higher than vascular (ND: 0.0087 ±0.0013, HFD: 0.0132 ±0.0050) regions. In particular, the kpl value in the medullar region exhibited a significant difference between the two diet groups. In summary, the feasibility of using modified SPICE for dynamic hyperpolarized 13 C MRSI was demonstrated via simulations and in vivo experiments. The consistency of spectral bases over time and the accuracy of the estimated kpl values validate the proposed acquisition scheme, which comprises only a single training dataset. The proposed method improved the spatial resolution of dynamic hyperpolarized 13 C MRSI, which could be used for kpl estimation using high signal-to-noise ratio spectral bases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | NMR IN BIOMEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dynamic hyperpolarized 13 C MR spectroscopic imaging using SPICE in mouse kidney at 9.4 T | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Jae Eun Song | - |
dc.contributor.googleauthor | Jaewook Shin | - |
dc.contributor.googleauthor | Hansol Lee | - |
dc.contributor.googleauthor | Young‐Suk Choi | - |
dc.contributor.googleauthor | Ho‐Taek Song | - |
dc.contributor.googleauthor | Dong‐Hyun Kim | - |
dc.identifier.doi | 10.1002/nbm.4230 | - |
dc.contributor.localId | A02080 | - |
dc.relation.journalcode | J02376 | - |
dc.identifier.eissn | 1099-1492 | - |
dc.identifier.pmid | 31856426 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/nbm.4230 | - |
dc.subject.keyword | SPectroscopic imaging by exploiting spatiospectral CorrElation | - |
dc.subject.keyword | dynamic magnetic resonance spectroscopic imaging | - |
dc.subject.keyword | hyperpolarized 13C | - |
dc.subject.keyword | kidney imaging | - |
dc.subject.keyword | low-rank model | - |
dc.subject.keyword | partially separable function | - |
dc.subject.keyword | subspace model | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | 송호택 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e4230 | - |
dc.identifier.bibliographicCitation | NMR IN BIOMEDICINE, Vol.33(3) : e4230, 2020 | - |
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