0 56

Cited 0 times in

Proinflammatory Effects of Calprotectin in Graves' Orbitopathy

Authors
 Ji Won Kim  ;  JaeSang Ko  ;  JinJoo Kim  ;  Jin Sook Yoon 
Citation
 OCULAR IMMUNOLOGY AND INFLAMMATION, Vol.28(1) : 156-163, 2020 
Journal Title
 OCULAR IMMUNOLOGY AND INFLAMMATION 
ISSN
 0927-3948 
Issue Date
2020
Keywords
Calprotectin ; Graves’ orbitopathy ; inflammation ; orbital fibroblast ; thyroid eye disease
Abstract
Purpose: Early detection and control of inflammation are important to manage Graves' orbitopathy (GO). We investigated the effects of calprotectin (S100A8/A9) on orbital fibroblast inflammation and GO pathogenesis.Methods: We measured serum calprotectin, S100A8 and S100A9 mRNA expression in orbital fat/connective tissue from GO patients and healthy controls, and proinflammatory cytokines in primary cultured orbital fibroblasts.Results: The serum levels of S100A8/A9 and the expression of S100A8/A9 mRNA in orbital tissue were higher in the GO patients than in the healthy controls. The serum calprotectin levels positively correlated with the clinical activity score and serum thyroid-stimulating immunoglobulin levels. In cultured GO orbital fibroblasts, S100A8/A9 increased the expression of interleukin (IL)-6, IL-8, and monocyte chemotactic protein-1, as well as the phosphorylation of extracellular signal-regulated kinase and nuclear factor-κB.Conclusion: We demonstrated the potential of calprotectin as a biomarker of GO severity and proinflammatory responses to S100A8/A9 in GO orbital fibroblasts.
Full Text
https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1547835
DOI
10.1080/09273948.2018.1547835
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Jaesang(고재상) ORCID logo https://orcid.org/0000-0002-3011-7213
Kim, Ji Won(김지원)
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175528
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse