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유방암 수술 후 액와림프절 재발 진단에 있어서의 미세침세척액 CYFRA 21-1의 진단적 가치
DC Field | Value | Language |
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dc.contributor.author | 김민정 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 박영진 | - |
dc.contributor.author | 윤정현 | - |
dc.contributor.author | 원소연 | - |
dc.date.accessioned | 2020-02-26T06:52:21Z | - |
dc.date.available | 2020-02-26T06:52:21Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1738-2637 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175321 | - |
dc.description.abstract | Purpose The objective of this study was to evaluate the diagnostic value and threshold levels of cytokeratin fragment 21-1 (CYFRA 21-1) in fine-needle aspiration (FNA) washouts for detection of lymph node (LN) recurrence in postoperative breast cancer patients. Materials and Methods FNA cytological assessments and CYFRA 21-1 measurement in FNA washouts were performed for 64 axillary LNs suspicious for recurrence in 64 post-operative breast cancer patients. Final diagnosis was made on the basis of FNA cytology and follow-up data over at least 2 years. The concentration of CYFRA 21-1 was compared between recurrent LNs and benign LNs. Diagnostic performance and cut-off value were evaluated using a receiver operating characteristic curve. Results Regardless of the non-diagnostic results, the median concentration of CYFRA 21-1 in recurrent LNs was significantly higher than that in benign LNs (p < 0.001). The optimal diagnostic cut-off value was 1.6 ng/mL. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CYFRA 21-1 for LN recurrence were 90.9%, 100%, 100%, 98.1%, and 98.4%, respectively. Conclusion Measurement of CYFRA 21-1 concentration from ultrasound-guided FNA biopsy aspirates showed excellent diagnostic performance with a cut-off value of 1.6 ng/mL. These results indicate that measurement of CYFRA 21-1 concentration in FNA washouts is useful for the diagnosis of axillary LN recurrence in post-operative breast cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한영상의학회 | - |
dc.relation.isPartOf | Journal of the Korean Society of Radiology (대한영상의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암 수술 후 액와림프절 재발 진단에 있어서의 미세침세척액 CYFRA 21-1의 진단적 가치 | - |
dc.title.alternative | Diagnostic Value of CYFRA 21-1 Measurement in Fine-Needle Aspiration Washouts for Detection of Axillary Recurrence in Postoperative Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | 원소연 | - |
dc.contributor.googleauthor | 김은경 | - |
dc.contributor.googleauthor | 문희정 | - |
dc.contributor.googleauthor | 윤정현 | - |
dc.contributor.googleauthor | 박영진 | - |
dc.contributor.googleauthor | 김민정 | - |
dc.identifier.doi | 10.3348/jksr.2020.81.1.147 | - |
dc.contributor.localId | A00473 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A01572 | - |
dc.contributor.localId | A02595 | - |
dc.relation.journalcode | J01843 | - |
dc.identifier.eissn | 2288-2928 | - |
dc.subject.keyword | Antigen CYFRA21.1 | - |
dc.subject.keyword | Postoperative Period | - |
dc.subject.keyword | Lymph Nodes, Pathology | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Biopsy, Fine-Needle | - |
dc.contributor.alternativeName | Kim, Min Jung | - |
dc.contributor.affiliatedAuthor | 김민정 | - |
dc.contributor.affiliatedAuthor | 김은경 | - |
dc.contributor.affiliatedAuthor | 문희정 | - |
dc.contributor.affiliatedAuthor | 박영진 | - |
dc.contributor.affiliatedAuthor | 윤정현 | - |
dc.citation.volume | 81 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 156 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society of Radiology (대한영상의학회지), Vol.81(1) : 147-156, 2020 | - |
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