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Microchannel network hydrogel induced ischemic blood perfusion connection

DC FieldValueLanguage
dc.contributor.author강미란-
dc.contributor.author김대현-
dc.contributor.author백우열-
dc.contributor.author성학준-
dc.contributor.author이정복-
dc.date.accessioned2020-02-26T06:50:31Z-
dc.date.available2020-02-26T06:50:31Z-
dc.date.issued2020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175309-
dc.description.abstractAngiogenesis induction into damaged sites has long been an unresolved issue. Local treatment with pro-angiogenic molecules has been the most common approach. However, this approach has critical side effects including inflammatory coupling, tumorous vascular activation, and off-target circulation. Here, the concept that a structure can guide desirable biological function is applied to physically engineer three-dimensional channel networks in implant sites, without any therapeutic treatment. Microchannel networks are generated in a gelatin hydrogel to overcome the diffusion limit of nutrients and oxygen three-dimensionally. Hydrogel implantation in mouse and porcine models of hindlimb ischemia rescues severely damaged tissues by the ingrowth of neighboring host vessels with microchannel perfusion. This effect is guided by microchannel size-specific regenerative macrophage polarization with the consequent functional recovery of endothelial cells. Multiple-site implantation reveals hypoxia and neighboring vessels as major causative factors of the beneficial function. This technique may contribute to the development of therapeutics for hypoxia/inflammatory-related diseases.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMicrochannel network hydrogel induced ischemic blood perfusion connection-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorJung Bok Lee-
dc.contributor.googleauthorDae-Hyun Kim-
dc.contributor.googleauthorJeong-Kee Yoon-
dc.contributor.googleauthorDan Bi Park-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorWooyeol Baek-
dc.contributor.googleauthorMi-Lan Kang-
dc.contributor.googleauthorHyun Jung Kim-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1038/s41467-020-14480-0-
dc.contributor.localIdA05812-
dc.contributor.localIdA04717-
dc.contributor.localIdA04717-
dc.contributor.localIdA04949-
dc.contributor.localIdA04949-
dc.contributor.localIdA01958-
dc.contributor.localIdA01958-
dc.contributor.localIdA05705-
dc.contributor.localIdA05705-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid32001693-
dc.contributor.alternativeNameKang, Mi-Lan-
dc.contributor.affiliatedAuthor강미란-
dc.contributor.affiliatedAuthor김대현-
dc.contributor.affiliatedAuthor김대현-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor이정복-
dc.contributor.affiliatedAuthor이정복-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage615-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.11(1) : 615, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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